MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Dystonia: Pathophysiology"

  • 2016 International Congress

    Botulinum toxin A injections changes sensorimotor network activations in cervical dystonia to state more related to physiological condition

    M. Nevrly, P. Hlustik, P. Otruba, P. Hok, Z. Tudos, P. Kanovsky (Olomouc, Czech Republic)

    Objective: To evaluate botulinum toxin A (BoNT-A) effectiveness on network in sensorimotor circuits. Background: Involvement of many cerebellar structures, such basal ganglia, thalamus, cerebellum, premotor…
  • 2016 International Congress

    Effects of cerebellar theta-burst stimulation on arm and neck movement kinematics in patients with focal dystonia

    M. Bologna, G. Paparella, A. Fabbrini, G. Leodori, L. Rocchi, M. Hallett, A. Berardelli (Pozzilli, Italy)

    Objective: To investigate the influence of the cerebellum on the motor cortex in primary focal dystonia using cerebellar continuous theta-burst stimulation (cTBS) and to evaluate…
  • 2016 International Congress

    Sensory gating and inhibition in dystonia

    E. Antelmi, R. Erro, L. Rocchi, R. Liguori, M. Tinazzi, J. Rothwell, K. Bhatia (Bologna, Italy)

    Objective: By performing an extensive evaluation of neurophysiological measurements accounting for inhibitory mechanisms within the S1, we aim to find if a central nervous system…
  • 2016 International Congress

    Dystonia after peripheral nerve injury in DYT1 transgenic rats

    S. Knorr, K. Grundmann-Hauser, J. Volkmann, C.W. Ip (Wuerzburg, Germany)

    Objective: To trigger a dystonic phenotype in a non-dystonic rat DYT1 model by inducing a peripheral nerve injury and to describe a new clinical scoring…
  • 2016 International Congress

    Digitally captured Archimedes spiral indices correlate with clinical assessment of dystonia severity

    J.B. Ratliff, A. Mirallave, R. Ortega, A. Glickman, Q. Yu, D. Raymond, S. Bressman, S. Pullman, R. Saunders-Pullman (New York, NY, USA)

    Objective: To determine whether digitized spiral analysis captures severity of dystonia in comparison to motor scores from the clinical gold standard, the Burke-Fahn-Marsden rating scale…
  • 2016 International Congress

    Robust sensorimotor deficits in a knock-in mouse model of primary torsion dystonia

    F. Richter, J. Gerstenberger, A. Bauer, C. Helmschrodt, A. Richter (Leipzig, Germany)

    Objective: The aim of present study was to (1) generate more powerful tests to detect robust behavioral alterations in the DYT1 knock-in mouse model of…
  • 2016 International Congress

    A dynamic causal model of the superior colliculus: Inhibitory activity increases with the temporal discrimination threshold

    B. Quinlivan, R. Moran, E. McGovern, S. Narasimham, I. Beiser, L. Williams, O. Killian, R. Beck, S. O'Riordan, J.S. Butler, M. Hutchinson, R.B. Reilly (Dublin, Ireland)

    Objective: To investigate if abnormalities observed in the putamen of unaffected first-degree relatives (of cervical dystonia patients) with abnormal temporal discrimination thresholds (TDT) are a…
  • 2016 International Congress

    Pallidal low frequency activity correlates with dystonic symptoms in patients with cervical dystonia

    W.J. Neumann, J. Huebl, C. Brücke, C. Slentz, G.H. Schneider, A.A. Kühn (Berlin, Germany)

    Objective: The aim of this study was to investigate the potential association between pallidal 4–12 Hz activity and symptom severity as quantified by the Toronto…
  • 2016 International Congress

    Faithful SGCE imprinting in iPSC-derived cortical neurons: An endogenous model system of myoclonus-dystonia

    K. Grütz, P. Seibler, A. Weißbach, K. Lohmann, F.A. Carlisle, D.J. Blake, A. Westenberger, C. Klein, A. Grünewald (Lübeck, Germany)

    Objective: To test the potential of induced pluripotent stem cell (iPSC)-derived cortical neurons from Myoclonus-dystonia (M-D) patients when studying specific epigenetic and brain-specific aspects of…
  • 2016 International Congress

    Mental simulation of whole-body movements in patients with isolated cervical dystonia

    M. Esposito, C. Vitale, F. Falco, S. Corvino, R. Allocca, S. Peluso, G. Santangelo, M. Conson (Naples, Italy)

    Objective: To explore mental transformation of whole-body images in patients with isolated cervical dystonia (CD). Background: Mental transformation of bodies or of body-part images is…
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