Multimodal neuroimaging during motor tasks in upper limb dystonia
Objective: To investigate brain activation and connectivity dynamics in individuals with idiopathic dystonia during motor tasks using Electroencephalography (EEG), Functional Magnetic Resonance (fMRI) and Functional…Unlocking dystonia from Parkinson’s disease (PD) with directional deep brain stimulation (DBS)
Objective: To investigate dystonia associated with PD in patients undergoing unilateral subthalamic nucleus (STN) DBS implantation. Background: Dystonia is a twisting, involuntary movement that often…DystoniaNet: Neural Biomarker-Based Platform for Dystonia Diagnosis using Deep Learning
Objective: Development and validation of a deep learning algorithmic platform for the identification of a microstructural biomarker for objective, accurate, and rapid diagnosis of dystonia.…Distinct maladaptive and compensatory wiring patterns in penetrant and non-penetrant dystonia mutation carriers
Objective: DYT1 and DYT6 are autosomal dominant mutations for primary dystonia with incomplete penetrance. We have found that expression levels for a distinct dystonia-related functional…The Impact of the Sensory Trick on Gating Multimodal Afferents in Cervical Dystonia
Objective: To investigate how ST modulate the postural sway in patients with idiopathic cervical dystonia (iCD) when proprioceptive and vestibular stimulation are provided simultaneously. Background: We…Striatal neurodegeneration in the presymptomatic phase of X-linked Dystonia-Parkinsonism
Objective: To identify structural brain changes in patients with X-linked dystonia-parkinsonism (XDP) and non-manifesting carriers of the TAF1 SVA retrotransposon insertion (NMC). Background: XDP is…Fractal analysis of muscle ultrasound imaging to evaluate muscle health and spasticity
Objective: The aim was to assess the capabilities of using fractal analysis of neuromuscular ultrasound images to evaluate muscle health and spasticity. Background: Ultrasound (US)…Characterization of pallidal neuronal activity in X-linked dystonia-parkinsonism – a model disease for compartment degeneration in the striatum
Objective: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is a highly effective symptomatic therapy for dystonia in X-linked dystonia-parkinsonism (XDP). A deeper…Writer’s Cramp Dystonia during increasingly complex motor task: analysis of behavior and task fMRI
Objective: To evaluate the relationship between clinical features of dystonia and striatal BOLD activity. Background: Dystonia is a brain disorder which causes involuntary twisting movements, abnormal…A novel phasic and restricted basal ganglia thalamocortical subcircuitry model
Objective: To advance a novel basal ganglia thalamocortical (BGTC) model that accounts for GPi as a tonic-burst mode regulator of the thalamus and for restricted…
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