SAGE-324/BIIB124, an investigational GABAA receptor PAM, for treatment of essential tremor
Objective: KINETIC2 is a multicenter, randomized, placebo-controlled, dose-response Ph2b study evaluating SAGE-324/BIIB124 for treatment of essential tremor (ET). Background: ET is a common movement disorder1,2…Vim DBS for Post-Stroke Tremor: A Case Report
Objective: We report a unique case of post-stroke tremor (PST) with a robust response to deep brain stimulation (DBS) of the ventral intermediate nucleus of…Tractography-guided versus Clinical Determination of the Most Effective Contact for Tremor Control in Patients with Deep Brain Stimulation – A Clinical Trial
Objective: To prospectively test the hypothesis whether imaging-guided contact selection based on standardized individual tractography of the dentato-rubro-thalamic tract (DRTT) is non-inferior to clinical contact…Clinical Assessment Of Dysautonomia And REM Sleep Behavior Disorders in Essential Tremor
Objective: To assess the frequency of Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) and dysautonomic symptoms in Essential Tremor (ET) patients and to identify…Once-Daily Suvecaltamide Pharmacokinetics, Safety, & Tolerability–Phase 1, Randomized, Double-Blind, Multiple Ascending Dose Study
Objective: Evaluate the pharmacokinetics (PK), safety, and tolerability of a once-daily (QD) suvecaltamide (JZP385) formulation and its major active metabolites (JZZ05000034=M01, JZZ05000035=M02) in a Phase…Deep brain stimulation of bilateral ventral intermediate nucleus in patients with neuronal intranuclear inclusion disease
Objective: To evaluate the effect and the side effects of deep brain stimulation on the tremor of a patient with neuronal intranuclear inclusion disease (NIID).…Dentato-Rubro-Thalamic Tract Deep Brain Stimualtion for Essential Tremor: Stimulation Parameters and Clinical Outcomes
Objective: To assess the stimulation parameters and 2-year clinical outcomes of deep brain stimulation (DBS) of the dentato-rubro-thalamic tract (DRTt) for the treatment of essential…Changes In Glucose Metabolism In Essential Tremor: Within And Beyond The Cerebello-Thalamo-Cortical Circuit
Objective: To investigate differences in brain glucose metabolism between patients with essential tremor and healthy controls using [18F]FDG PET brain imaging. Background: The pathophysiological mechanisms…Essential3: An Innovative Multi-Study Phase 3 Program to Evaluate the Efficacy and Safety of Ulixacaltamide
Objective: An innovative, multi-study Phase 3 program to definitively assess safety and efficacy of ulixacaltamide in essential tremor (ET). Background: Phase 2 studies of ulixacaltamide,…Is Neuropsychological Evaluation Needed to Assess DBS Candidacy in Essential Tremor?
Objective: In this study we examined frequency of cognitive and psychiatric disorders identified during neuropsychological evaluation for Deep Brain Stimulation (DBS) in patients with Essential…
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