Exercise Mitigates DNA Methylation Changes at cg17274742 Associated with the Circadian Gene Variant PER2 rs2304672: A Biobank Analysis
Objective: This research aims to dissect the influence of physical activity and circadian rhythms on neuroinflammation and neurodegenerative disease progression, focusing on Parkinson's Disease (PD).…Immunomodulatory Effects Of Covid-19 Vaccination On Inflammatory And Neurotrophic Factors In Parkinson’s Disease: Insights From Clinical Subtypes
Objective: This study investigates the impact of COVID-19 vaccination on levels of interleukin 6 (IL-6) and brain-derived neurotrophic factor (BDNF) in patients with Parkinson's disease…Single cell transcriptomics of peripheral blood mononuclear cells and associations with clinical outcomes in Parkinson’s disease
Objective: To assess transcriptomics signatures for monocytes and T-cells in different stages of Parkinson’s disease (PD) compared to controls and possible correlations with clinical outcomes.…Baseline fluid biomarkers in a phase 2 clinical trial in Parkinson’s Disease
Objective: To evaluate baseline CSF and blood-based biomarkers of pathology in early-stage Parkinson’s Disease (PD) participants in the phase 2 clinical trial PASADENA. Background: Observational…GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase shows evidence of pharmacological efficacy in an animal model of Parkinson’s disease.
Objective: To investigate the effect of the structurally targeted allosteric regulator GT-02287 on rotenone-induced neurotoxic effects in a Parkinson’s disease animal model. Background: Mutations in…Axial impairment and bradykinesia are related to increased CSF sTREM2, a neuroinflammation biomarker, in Parkinson’s disease
Objective: To explore the association between Parkinson’s disease (PD) motor symptoms and CSF biomarkers for neuroinflammation and neurodegeneration. Background: Previous in vivo and post mortem…Evaluation of neuroprotective role of carvacrol via Nrf2-NLRP3 axis in rotenone induced PD mice model
Objective: To explore the antioxidant and anti-inflammatory role of Carvacrol via Nrf2-NLRP3 axis in rotenone induced PD mice model Background: NLRP3 inflammasome mediated neuroinflammation is…RNA editing contributes to the inflammatory astrocytic response in Parkinson’s disease.
Objective: 1) Using an IPSC derived cell model to explore astrocytic responses alone and cocultured neurons to alpha-synuclein oligomer (αsynO) treatment.2) Determine the extent to…The Role of Adaptive Immunity caused by α-synuclein Recognition Specific Sequence Peptide on the Onset of Parkinson’s Disease Pathogenesis
Objective: We investigated whether α-synuclein-derived peptides (recognized specific sequence in α-synuclein) can drive T-cell response and evaluated the neurotoxicity of α-synuclein peptide-specific T-cell in Parkinson’s…Non-invasive Vagus Nerve Stimulation Alters Molecular Markers in Parkinson’s Disease Patients with Freezing of Gait
Objective: To investigate molecular mechanisms underlying non-invasive vagus nerve stimulation (nVNS) in Parkinson’s disease (PD) patients with freezing of gait (FOG). Background: FOG remains one…
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