Comparison of four DBS lead designs under voltage and current operating modes based on patient specific simulations
Objective: To quantitatively compare the spatial extension of the electric field generated by four different lead designs operated under voltage and current modes. Background: Conventional…Safety and clinical effects of NTCELL® [immunoprotected (alginate-encapsulated) porcine choroid plexus cells for xenotransplantation] in patients with Parkinson’s disease (PD): 81 to 130 weeks follow-up
Objective: To follow the clinical status of 4 PD patients transplanted with NTCELL out to 81-130 weeks. Background: NTCELL comprises neonatal porcine choroid plexus cells…Wearable sensors and decision algorithms for advanced therapy referral in Parkinson’s disease
Objective: Pilot study to determine the impact of remote monitoring using objective, wearable sensors on the advanced therapy referral rate in patients with advanced Parkinson's…Pathological findings from two Parkinson’s disease patients after intraputaminal GDNF infusion
Objective: To describe the postmortem findings from two patients who underwent intraputaminal infusion of glial-derived neurotrophic factor (GDNF). Background: GDNF has been shown to have…Impact of expiratory muscle strength training (EMST) on phonatory performance in Parkinson’s patients
Objective: The current study adopted a randomized control trial (RCT) design to investigate the impact of expiratory muscle strength training (EMST) on vocal loudness and…A clinical trials ‘charter’ to improve communication about, recruitment to and retention in Parkinson’s clinical trials
Objective: The objective of the project was to design a durable tool, usable by clinical trial investigators and participants alike, that would improve subject retention…Identification of barriers preventing disclosure of non-motor symptoms in Parkinson’s patients to healthcare providers
Objective: 1) To identify patient barriers to help-seeking for non-motor symptoms (NMS) from their Parkinson's healthcare provider, 2) To determine whether barriers are symptom specific…Utilizing remote blood pressure monitoring in a phase III clinical drug trial for Parkinson’s disease
Objective: To determine the feasibility and value of remote blood pressure (BP) monitoring during a clinical trial of isradipine (a dihydropyridine calcium channel antagonist) in…
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