Estimating the Meaningful Within-Patient Change Threshold for the MDS-UPDRS Part III
Objective: To estimate the meaningful within-patient worsening threshold (MWPWT) of the Movement Disorders Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS Part III in early-stage Parkinson's disease…A systematic review on physical health education interventions for people with Parkinson’s: content, impact and implementation considerations across Parkinson’s trajectory
Objective: To examine the content of education interventions that promote physical activity (PA) behavior in PwP, and to assess their effectiveness on physical and psychosocial…A Patient-Centered Outcomes Survey in Parkinson’s Disease: Results of Cognitive Pre-Testing
Objective: To validate the Rush Parkinson's Disease Patient-Centered Outcomes Questionnaire (RUSH-PCO-Q). Background: The RUSH-PCO-Q aims to address the lack of patient-centered outcomes in the field…Feasibility and acceptability of PDConnect: a collaborative approach to physical activity for people with Parkinson’s.
Objective: To evaluate the feasibility and acceptability of a novel collaborative telehealth based physical activity intervention for people with Parkinson’s. Background: The benefits of physical…A modified Delphi panel to establish a threshold of meaningful progression on MDS-UPDRS Part III
Objective: To establish a threshold for meaningful progression on MDS-UPDRS Part III in an early-stage Parkinson's disease (PD) population (Hoehn & Yahr [H&Y] Stage I–II)…The STEPWISE Parkinson study: a Smartphone Based Exercise Solution for Patients With Parkinson’s Disease
Objective: To investigate the feasibility of a smartphone app (STEPWISE app) to increase the physical activity level (i.e. number of steps) in people with Parkinson’s…Improving the design of clinical trials in early-stage Parkinson’s disease by using the estimand framework
Objective: To show how the estimand framework can be used to improve design of clinical trials testing treatments in early-stage Parkinson’s disease (PD). Background: The…Effect of exercise on brain metabolism and energetics in PD
Objective: To identity the effect of exercise on brain metabolism and energetics in PD using PET/MR imaging. Background: Aerobic exercise slows PD progression as reflected…NONINVASIVE BRAINSTEM MODULATION FOR THE TREATMENT OF NONMOTOR SYMPTOMS IN PARKINSON’S DISEASE: A RANDOMIZED CONTROLLED TRIAL AND OPEN LABEL EXTENSION STUDY
Objective: A multi-site double-blinded pivotal randomized controlled trial (RCT) with an open label extension (OLE) study has been initiated to evaluate the safety and efficacy…Time-to-event approach mitigates the treatment masking effect of symptomatics on MDS-UPDRS Part III
Objective: To assess whether a time-to-event (TTE) approach may mitigate the masking effect of changing symptomatic therapy on Movement Disorders Society–Unified Parkinson’s Disease (PD) Rating…
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