Understanding the role of LRRK2 in Indian population
Objective: Genomic approaches in Caucasian population show little transferability to other ethnically diverse populations such as Indian population. Understanding the genetic architecture of a disease…Assessing the response to L-dopa/carbidopa intestinal gel infusion (Deudopa) based on genetic status.
Objective: To asses genetic impact on dosage of L-dopa/carbidopa treatment Background: L-dopa/carbidopa intestinal gel infusion (LCIG) is a method of continuous dopaminergic stimulation used in…Comparison of the non-motor symptom assessment scale between LRRK2 G2019S positive versus matched control Parkinson disease
Objective: To compare the non-motor symptom assessment scale (NMSS) score between Leucine-rich repeat kinase 2 (LRRK2) mutation carriers with Parkinson disease (PD) and matched controls with…Caffeinated Drinks, LRRK2 Genotype and PD
Objective: To determine the role of caffeine containing drinks on penetrance in LRRK2-associated PD Background: LRRK2 penetrance is reduced for PD [1]. Environment and/or other…Interval from onset of Parkinson disease to onset of motor and non-motor complications in Leucine-rich repeat kinase 2 (LRRK2) G2019S positive versus matched PD controls
Objective: To compare the latency between onset of Parkinson disease (PD) symptoms and onset of motor and non-motor complications of PD, between G2019S LRRK2 mutation…Spiral Analysis is a Promising Biomarker in LRRK2 G2019S carriers
Objective: To assess whether harboring a LRRK2 G2019S mutation is associated with abnormalities in spiral drawing, including in mutation carriers with Parkinson Disease (PD) as…Screening of GBA and LRRK2 G2019S Mutations in Egyptian Parkinson’s Disease Patients
Objective: We aim to estimate the frequency of mutations in the glucocerebrosidase gene (GBA) and LRRK2 G2019S in a yet unstudied Egyptian Parkinson's disease population from the…Neuromelanin Magnetic Resonance Imaging of the Substatia Nigra in LRRK2 -related Parkinson’s disease
Objective: Our study aimed to evaluate neuromelanin-Magnetic Resonance signal changes in PD patients carrying a LRRK2 mutation. Background: Specific magnetic resonance (MR) sequences are able to…Data driven analysis for exploring phenotypic differences in patients with Parkinson’s disease with or without genetic mutations.
Objective: To explore, using a data driven statistical analysis method, discriminating phenotype features of disease in a large group of patients with Parkinson’s disease (PD)…Gene associated differences in pre-diagnostic symptoms of Parkinson’s Disease: a retrospective study
Objective: To investigate whether glucocerebrosidase (GBA) L444P and leucine-rich repeat kinase 2 (LRRK2) G2385R and R1628P mutations are associated with different symptoms and manifesting patterns…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.