Design of a Pharmacokinetics Study with Multiple Doses of Accordion Pill™ Carbidopa/Levodopa in Patients with Parkinson’s disease
Objective: To perform a pharmacokinetic (PK) study of the Accordion Pill™ carbidopa/levodopa (AP-CD/LD) and to determine if multiple doses can provide continuous delivery of LD.…A phase Ib trial studying the safety and tolerability of IRL790 in patients with Parkinson’s disease and levodopa-induced dyskinesia
Objective: The primary objective was to investigate the safety and tolerability of IRL790 in PD patients with LID in a randomized controlled trial. Background: IRL790…Comparative results between preoperative acute levodopa challenge test and deep brain stimulation
Objective: Our aim is to compare motor clinical benefits after acute levodopa challenge test, with those obtained further with deep brain stimulation (DBS). Background: DBS…Identification of L-DOPA “on/off” states using speech-based analysis in Parkinson’s disease subjects
Objective: The aim of this study is to assess the use of semantic, prosodic, and acoustic speech features to better characterize PD signs with respect…Future doctors as health educators: Undergraduate medical students raise awareness and unite for Parkinson’s disease
Objective: To highlight the role of undergraduate students in raising the awareness about Parkinson's disease among peers and public. Encouraging the students to take responsibility…The Interface of advanced therapies as Parkinson’s disease progresses – case reports
Objective: To explore the practical benefits and challenges of adding duodenal levodopa-carbidopa intestinal gel infusion (LCIG) to subthalamic nucleus deep brain stimulation (STN DBS) in…Safety and Efficacy of Levodopa-Carbidopa Monotherapy in Patients with Advanced Parkinson’s Disease
Objective: Evaluate efficacy/safety of levodopa-carbidopa intestinal gel (LCIG) daytime monotherapy (with/without nighttime oral carbidopa/levodopa) vs polytherapy (LCIG with >1 adjunctive therapy) in advanced Parkinson’s disease…Patient’s Choice of Device-Based Treatments in Parkinson’s Disease
Objective: Deep brain stimulation of subtalamic nucleus (STN-DBS), subcutaneous apomorphine infusion (APO) and levodopa-carbidopa intestinal gel infusion (DUO) is routinely used in patients with advanced…Polymorphisms of glutamatergic system genes are associated with levodopa-induced dyskinesia in Parkinson’s disease
Objective: We aimed to study the association between glutamatergic system gene polymorphisms (SLC1A2 – gene, coding excitatory acids transporter, and GRIN2A gene, coding a subunit…Long Term Response to L-dopa in Parkinson Disease
Objective: To assess the long-term effectiveness of levodopa in Parkinson’s disease (PD) patients. Background: To date, levodopa continues to be the most efficacious drug in…
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