Seed Amplification Assay Is More Sensitive To Detecting α-Synuclein In Gut Biopsies Than Immunohistochemistry
Objective: Assess seed amplification assay (SAA) and immunohistochemistry (IHC) in peripheral gut mucosal biospecimens as PD diagnostics. Background: SAA detects misfolded alpha-synuclein (α-syn) aggregates across…Proximity Ligation Assay Reveals Early Tractopathy in Parkinson’s Disease
Objective: To determine how α-synuclein (αSyn) pathology extends beyond the neuronal soma in the anterior cingulate cortex (ACC) by mapping early pathological changes within adjacent…Sex differences for clinical impact of APOEe4 mediated by Alzheimer’s pathology in people with Lewy body pathology
Objective: Assess whether Alzheimer’s (AD) or Lewy body (LB) pathologies mediate the association between APOEe4 and clinical profile differently for females and males with LB…α-Synuclein biomarkers in prodromal synucleinopathies: a systematic review and meta-analysis.
Objective: To quantify the diagnostic accuracy and predictive performance of α-synuclein biomarkers in isolated REM sleep behaviour disorder (iRBD), pure autonomic failure (PAF), and idiopathic…Senile Plaques and Neurofibrillary Tangles Modulate Lewy Body Distribution: Autopsy Study of 2,308 Cases
Objective: To understand how Lewy body (LB) pathology progresses in the cerebrum and how Alzheimer's disease (AD) pathology influences LB distribution in LB disease (LBD).…Genetic Rare Variation in Early-Onset Neurodegenerative Movement Disorders: A Clinicopathologic Study.
Objective: To evaluate rare genetic variants in early-onset movement disorder (MD) cases in relation to neuropathology. Background: Accurate diagnosis of neurodegenerative MDs is complicated by…Patient-Derived α-Synuclein Kinetic Subtypes Drive Distinct Pathological Propagation Patterns and Brain Network Alterations in Parkinson’s Disease Mouse Models
Objective: To validate whether patient-derived α-synuclein (α-Syn) aggregates with distinct kinetic properties produce differentiated pathological propagation patterns, brain network functional alterations, and behavioral phenotypes in…A Diffusion MRI Neurodegeneration Index for Lewy Body Dementia & Alzheimer’s disease
Objective: To develop a diffusion MRI-based neurodegeneration index using free-water imaging and assess its ability to quantify neurodegenerative burden in Lewy body dementia (LBD) and…Insight into α-synuclein pathogenicity by a human cell model with suppressed NatB-mediated N-terminal acetylation
Objective: Our aim was to study α-syn Nt-acetylation and its impact on the disease-relevant properties of this protein in cell models to shed light on…Differences in Lewy body dementia in people from ethnic minorities: a systematic review of epidemiology, diagnosis, clinical features and imaging
Objective: To systematically review evidence on epidemiological and clinical differences in Lewy body dementia (LBD), including dementia with Lewy bodies (DLB) and Parkinson’s disease dementia…
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