Alpha-Synuclein Accumulation-Attenuating Effect of Brain-Derived Neurotrophic Factor in Primary Cell Culture Model of Parkinson’s Disease
Objective: To explore the role of neurotrophic signaling pathways in modulating the effect of brain-derived neurotrophic factor (BDNF) on pre-formed fibrils (PFFs)- induced alpha-synuclein (aSyn)…The Impact of Microgravity and Herpes Simplex Virus 1 on Parkinson’s Neurodegeneration and HERV Expression
Objective: The present abstract aims to investigate the impact of viral infections and microgravity exposure in the context of Parkinson’s disease (PD). Background: PD is…Amygdala-predominant Lewy Body Disease is a Lens for Understanding Pathogenesis and the Alpha-synuclein Seeding Assay in Human Postmortem Brain
Objective: To map alpha-synuclein (asyn) and tau markers in amygdala-predominant Lewy body disease (AP-LBD), identifying spread pathways and vulnerable cell populations. Background: LBD often co-occurs…GBA1 deficiency promotes the spread of Lewy pathology
Objective: To elucidate how GBA1 deficiency promotes the spread of Lewy pathology from cell to cell. Background: Mutations in the gene glucosidase, beta acid 1 (GBA1) not…Spatial Multi-Omics Identifies Early Synaptic Pruning and Context-Specific Dopaminergic Vulnerability in Synucleinopathies
Objective: To investigate the significance of Lewy body pathology (LBP) in relation to midbrain molecular and cellular changes associated with Parkinson's disease (PD). Background: The…Ventral and Dorsal Language Pathways in Patients with Lewy Bodies: an fMRI Study of Syntactic Sentence Processing
Objective: Aim of this study is to describe specific alterations in comprehending syntactically complex sentences in patients with Lewy body diseases (LBDs) that already have…Identifying Cut-off Values, Effects of AD Co-pathology, Sex Differences, and Temporal Changes of 123I-FP-CIT SPECT in Autopsy-proven LBD
Objective: We analyzed autopsy-proven Lewy body disease (LBD) and/or Alzheimer’s disease (AD) dementia patients with 123I-FP-CIT SPECT to investigate previously unclarified detailed aspects of 123I-FP-CIT…Seed amplification assay detects alpha-synuclein in cerebrospinal fluid in pre- and symptomatic autosomal dominant Alzheimer’s disease
Objective: To examine the ability to detect concurrent Lewy Body Disease via Lew Body pathology (LBP) in Autosomal Dominant Alzheimer’s Disease (ADAD) through detection of…Efficacy of Stimulant Use for Cognitive Fluctuations in Lewy Body Dementia: A Case Study
Objective: To evaluate the effectiveness of stimulants in reducing cognitive fluctuations in Lewy Body Dementia (LBD). Background: Lewy Body Dementia (LBD) is the 2nd most…Sex differences in regional densities of Lewy body pathology
Objective: To assess sex differences in regional Lewy body pathology densities and their clinical correlations in cases with Lewy body (LB) pathology at autopsy. Background:…
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