Concordance of Neuropathologic Diagnosis of Lewy Body Disease with Baseline Alpha-Synuclein Seed Amplification Assay in PPMI
Objective: To determine whether the alpha-synuclein seed amplification assay (aSyn-SAA) performed on cerebral spinal fluid (CSF) collected at the baseline (BL) PPMI visit is concordant…α-Synuclein Pathology Across Movement Disorders and Neurodegenerative Diseases by Seed Amplification Assay
Objective: To assess the frequency of pathological α-synuclein (αSyn) in various movement disorders and neurodegenerative diseases from a specialized movement disorder clinic by αSyn seed…Case Report: An Unusual Case of Corticobasal Syndrome
Objective: To describe a patient with corticobasal syndrome (CBS) and biomarker evidence of multiple proteinopathies. Background: CBS is a clinically heterogeneous syndrome caused by several…Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s Disease
Objective: To develop a technology capable of ultra-sensitive, in situ amplification of abnormal conformations of αSyn within biological samples, potentially enhancing diagnostic accuracy and shedding…Parkinson’s Disease Risk Genotypes at the GPNMB Locus Associate with Extent of Post-mortem Lewy Pathology
Objective: To determine whether Parkinson’s disease (PD) risk genotypes at the GPNMB locus associate with distribution of Lewy pathology in brain samples from a spectrum…Genetic determinants of the progression of Lewy body pathology
Objective: To identify genetic risk factors associated with the distribution of Lewy body (LB) and Alzheimer’s disease (AD) co-pathology in the Lewy body disease (LBD)…Assessment of variation in α-synuclein seed amplification assay results in the PPMI cohort: Association with hyposmia
Objective: To understand molecular heterogeneity among Parkinson’s disease (PD) patients, and controls based on α-synuclein seed amplification assay (SAA) results. Background: α-synuclein seed amplification assay…Health status of Lewy Body Dementia caregivers predicts psychological response to peer mentoring intervention
Objective: To understand how caregiver health status influences response to a peer mentoring intervention in caregivers of individuals with Lewy Body Dementia (LBD). Background: Caregiving…Sex differences for clinicopathological correlations in people with Lewy body pathology
Objective: To determine sex-specific clinical correlations of different Lewy body (LB), Alzheimer’s disease (AD) pathology staging and nigral neuron loss levels in people with LB…Impact of the severity of Parkinson’s disease on skin elasticity
Objective: To investigate changes in skin elasticity according to the severity of symptoms of Parkinson's disease. Background: Parkinson's disease (PD) is a neurodegenerative disease caused…
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