Addressing pathological alpha-synuclein aggregation using a small molecule strategy
Objective: The discovery of cell-permeable, orally bioavailable and brain penetrant small molecules with the potential of inhibiting aggregation and intracellular accumulation of pathological alpha-synuclein (a-syn)…Incidental Lewy Body disease and idiopathic Parkinson’s disease: from common pathogenic factors to the overlapping clinical features
Objective: To compare established early symptoms and risk factors associated with Parkinson’s disease (PD) in a cohort of incidental Lewy Body disease (iLBD) and healthy…Sex Modulates Cognitive Association of Lewy Body Pathology
Objective: To assess whether the association between Lewy body (LB) pathology stages and cognition differs for women and men Background: Progression of LB pathology is…Blaming neuromelanin for Parkinson’s disease: time-dependent tyrosinase overexpression drives endogenous synucleinopathy in non-human primates
Objective: Development and characterization of a novel non-human primate model of Parkinson’s disease based on the AAV-mediated forced expression of human tyrosinase Background: Although neuromelanin…Smoking and Substantia Nigra Neuron Density in the Presence and Absence of Lewy Pathology
Objective: Our objective is to examine the association of mid-life smoking with post mortem substantia nigra (SN) neuron density in the presence and absence of…Differential methylation signatures in Lewy body dementia
Objective: This study aimed to compare the DNA methylome of Lewy body dementia (LBD) patients and healthy controls. Background: LBD is the second most common…Sex-Specific APOE ε4 Association with Cognition in Lewy Body Dementia
Objective: To evaluate whether association between apolipoprotein E ε4 (APOE ε4) and cognition differ for men and women with pathologically-confirmed Lewy body dementia (LBD). Background:…Association between Alzheimer’s disease co-pathology and neuropsychiatric symptoms in Lewy body dementia
Objective: To identify the associations between Alzheimer Disease (AD) co-pathology and neuropsychiatric symptoms in Lewy body dementia (LBD). Background: Dementia with Lewy Bodies (DLB) and…Olfactory dysfunction in incidental Lewy body disease and Parkinson’s disease: An update
Objective: Using a larger sample size compared to our previous study, we evaluated the relationship between olfactory dysfunction based on the University of Pennsylvania Smell…Tau Neuropathology Associates with In Vivo Patterns of Neurodegeneration in Lewy Body Disorders
Objective: Investigate the impact of Alzheimer’s disease (AD) co-pathology on an in vivo structural measure of neurodegeneration in Lewy Body disorders (LBD: Parkinson’s Disease and…
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