Serum cholesterol levels over time and risk of Parkinson’s disease
Objective: To evaluate the association of serum cholesterol levels over time with the risk of Parkinson's disease (PD); among statin-free individuals. Background: High levels of…Neuroactive steroids reverse the dopaminergic neurotransmission defectiveness in chronic hepatic (HE) encephalopathy: a possible involvement in HE related parkinsonism
Objective: In the present study, we describe the changes of the dopaminergic system occurring in the cirrhotic rats and concomitantly we investigated the effect of…Investigating the Lipidomic Signature of Spinocerebellar Ataxia (SCA1) Using A Liquid-Microjunction Surface Sampling Probe
Objective: Lipidomic analysis of mice with spinocerebellar ataxia by mass spectrometry. Background: Ataxia is a movement disorder affecting balance and coordination of limbs, gait, eyes…Alterations in lipid metabolism modify GBA1-mediated neurodegeneration in a Drosophila model of Parkinson’s disease
Objective: To understand how glucocerebrosidase (GBA1) mutations increase susceptibility to Parkinson's disease (PD). Background: Our understanding of the pathogenesis PD remains limited, and currently no…Elevated GM3 Plasma Concentration in Idiopathic Parkinson’s Disease: a Lipidomics Analysis
Objective: To test the association between plasma lipids and Parkinson disease (PD) diagnosis. Background: PD is a common neurodegenerative disease whose pathological hallmark is the…Mitochondrial cardiolipin couples electron transport between ubiquinone and complex I to rescue PINK1 deficiency
Objective: Test the effect of loss of FASN on Pink1 deficiency. Background: PINK1 deficiency causes Parkinson's disease that is based on mitochondrial defects including inefficient…Coding and non-coding glucocerebrosidase variants have an impact on cognitive decline in Parkinson’s disease
Objective: To evaluate the impact of genetic variants in the Glucocerebrosidase gene (GBA) on cognitive impairment in a large cohort of Parkinson's disease (PD) patients…Molecular landscape of Parkinson’s disease reveals a key role for lipids and lipoproteins
Objective: Integrate available genetic and expression data to generate a molecular landscape of Parkinson's disease (PD) in order to identify key disease mechanisms that may…The association between structural brain connectivity with plasma APO-A1 levels in Parkinson’s disease: Connectometry approach
Objective: Features of the lipid profile specially cholesterol levels are association with PD risk. However no such data exists on the association of these plasma…Plasma ceramides and glucosylceramides predict cognitive decline among cognitively normal Parkinson’s disease patients
Objective: To determine whether plasma ceramides, glucosylceramides, and their ratios predict cognitive decline among cognitively normal Parkinson's disease (PD) patients. Background: There are no biomarkers…
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