Multimodal Quantitative MRI Improves Parkinson’s Disease Classification
Objective: To evaluate multimodal MRI discrimination of Parkinson’s disease using RPCA–kNN and associations with MDS-UPDRS. Background: Parkinson’s disease (PD) involves progressive neurodegeneration affecting basal ganglia…Examining the Impact of Fatigue on White Matter tracts in Parkinson’s Disease
Objective: To determine whether people with Parkinson’s disease (PwPD) with fatigue, and those without fatigue, experience differences in white matter structural connectivity (SC). Background: Fatigue…Data-driven Trajectories of Atrophy Explain Clinical Heterogeneity Across Lewy Body Diseases
Objective: To identify data-driven spatiotemporal trajectories of brain atrophy across the Lewy body disease spectrum and establish their relationship to clinical heterogeneity, core symptom profiles,…Regional Basal Ganglia Hypoperfusion in Early Parkinson’s Disease: Evidence from CT Perfusion Imaging
Objective: To characterize region-specific cerebral perfusion alterations within the basal ganglia in patients with early-stage Parkinson's disease using quantitative CT perfusion imaging. Background: Emerging evidence…Reconfiguration of Structural-Functional Coupling Associated with Clinical Features and 5-Year Progression in Parkinson’s Disease: A Cross-sectional and Longitudinal Study
Objective: This study aimed to characterize Structural–functional coupling (SFC) reorganization in Parkinson’s disease (PD), examine its associations with motor and cognitive performance, and assess whether…Distinct Patterns of Perivascular Diffusivity and Choroid Plexus Volume in De Novo Parkinson’s Disease and Type 2 Diabetes
Objective: This study aimed to investigate the differences in perivascular water diffusivity and structural neurofluid markers using diffusion tensor image-analysis along the perivascular space (DTI-ALPS),…Basal Ganglia Hypointensity Associated with Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS)
Objective: To present a new case of glucose transporter type 1 deficiency syndrome (GLUT1-DS) diagnosed in adulthood and to describe the associated radiological findings. Background:…Mitochondrial Density Shapes Regional Vulnerability to Atrophy in Parkinson’s Disease
Objective: To characterise the coupling between regional mitochondrial density and complex I activity and spatially patterned brain atrophy in Parkinson's disease (PD), and its variation…Dual-Site Transcranial Magnetic Stimulation Ameliorates Freezing of Gait in Parkinson’s Disease by Remodeling Cortical Excitatory-Inhibitory Balance and White Matter Microstructure: A Randomized Controlled Trial
Objective: To investigate whether dual-site [DS, primary motor cortex (M1) + supplementary motor area (SMA)] repetitive transcranial magnetic stimulation (rTMS) could attain superior efficacy compared…White Matter Hyperintensity and the Spatial Subtypes in Parkinson’s Disease
Objective: To determine whether white matter hyperintensity (WMH) volume and its spatial subtypes, periventricular WMH (PWMH) and deep WMH (DWMH), are associated with cognitive impairment…
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