Cross-Sectional and Longitudinal MRI Biomarkers of Neurodegeneration in Friedreich’s Ataxia
Objective: - To identify structural CNS changes associated with Friedreich’s ataxia (FRDA).- To characterize their longitudinal progression. Background: Friedreich’s ataxia (FRDA), the most common inherited…Genetic Architecture Of Intracranial Brain Calcification: A Systematic Review
Objective: To systematically identify monogenic disorders associated with intracranial intraparenchymal brain calcification and synthesise their clinical, radiological and molecular features. Background: Brain calcification is a…Regional Homogeneity in the Visual Network Mediates between Microbiota and Cognition in Parkinson’s Disease
Objective: We study the role of spontaneous brain activity in the cross-talk between gut microbiota and cognition in PD. Background: Gut dysbiosis is a prevalent…Investigating Substantia Nigra Microstructural Integrity as a Potential Predictive Biomarker for Fall Burden in Parkinson’s Disease
Objective: Determine whether baseline Diffusion Tensor Imaging (DTI) measures of the substantia nigra (SN) predict fall incidence and burden in Parkinson’s disease (PD). Background: Degeneration of dopaminergic…Can Parkinson’s Disease and Progressive Supranuclear Palsy be Distinguished Using Surgical Planning Image Analysis Software?
Objective: During deep brain stimulation (DBS), the surgical planning software Elements can automatically identify deep brain structures and calculate their volumes. This procedure is straightforward…Automatic Segmentation of the Subthalamic Nucleus and Globus Pallidus Internus: Can it support planning and programming in Deep brain stimulation
Objective: Whether auto-segmentation matches anatomy?Whether auto-segmentation volume difference in either side matches UPDRS score difference between two sides?whether auto-segmentation volume depends on MRI sequence?Whether auto-segmentation…Beyond Motor Symptoms: Utilizing the FreeSurfer Brainstem Substructures Module to Characterize a Complex Parkinsonian Phenotype with Profound Dysautonomia
Objective: To describe the autonomic function profile and quantitative brainstem substructures analysis in a 62-year-old male of Parkinsonism complicated by severe autonomic failure and neuropsychiatric…Cortical Mean Diffusivity as a Measure of Microstructural Neurodegeneration in Multiple System Atrophy
Objective: To characterize cortical microstructural alterations in multiple system atrophy (MSA) and to examine their associations with clinical features and neuropsychological performance. Background: Cortical mean…Machine Learning–Based Brain Age Modeling Reveals Accelerated Structural Degeneration in Parkinson’s Disease
Objective: To compare the rate of global brain structural degeneration between healthy controls (HC) and patients with Parkinson’s disease (PD). Background: Normal aging is accompanied…Image-Guided DBS Programming in Dystonia: Experience from a Tertiary Public Brazilian Center
Objective: To illustrate the clinical utility of postoperative DBS lead reconstruction and image-guided programming in genetic dystonia Background: DBS of the globus pallidus internus (GPi)…
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