Fluid Biomarkers and the 4R-Tauopathies
Objective: To investigate the prevalence and clinical relevance of AD co-pathology, assessed through fluid biomarkers, in patients with clinical 4R-tauopathies. Background: 4R-tauopathies are neurodegenerative diseases…Relationship Between Alpha-Synuclein Aggregation Profiles, Imaging Biomarkers, and Disease Severity in a Phase 2 Study of ATH434 in MSA
Objective: To investigate the relationships between α-synuclein aggregation profiles, imaging biomarkers, and UMSARS I scores in the ATH434-201 Phase 2 study. Background: Multiple system atrophy…Correlations of plasma glial fibrillary acidic protein levels with glymphatic system impairment in Huntington’s disease
Objective: To investigate whether plasma glial fibrillary acidic protein (GFAP) levels are related to glymphatic system function in Huntington's disease (HD). Background: Plasma GFAP levels has…Longitudinal Brain Morphometric Trajectories Across Parkinson Disease Clinical Subtypes
Objective: To investigate longitudinal brain morphometric trajectories across Parkinson disease (PD) clinical subtypes Background: We developed a PD multi-domain classification based on motor and non-motor…Clinical And Cerebellar Structural Alterations In Parkinson’s Disease Patients With Freezing Of Gait
Objective: To assess clinical and cerebellar volume differences in Parkinson’s disease (PD) patients with and without freezing of gait (PD-FoG and PD-NOFoG). Background: Cerebellum plays…Atrophy In Multiple System Atrophy Relates To Mitochondrial And Oligodendrocytic Processes
Objective: To investigate the gene expression and neurobiological underpinnings of brain atrophy in MSA using imaging transcriptomics and PET-based molecular annotation Background: The biological mechanisms…Widespread White Matter Changes in Manifest Huntington’s Disease
Objective: To characterize white matter changes in Huntington’s Disease (HD). Background: HD is a genetic neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. Diffusion Tensor…χ-DBS: An Open-Source Susceptibility Atlas Tool for Deep Brain Stimulation Target Visualization and Segmentation
Objective: This work is motivated by the need for atlas creation tools for susceptibility maps presurgically acquired for deep brain stimulation (DBS). Segmentations aid in…Diffusion MRI Changes Linked to α-Synuclein Seed Amplification Status in Parkinson’s Disease
Objective: To compare free-water (FW) imaging in individuals with Parkinson’s disease (PD), with positive vs. negative cerebrospinal fluid (CSF) α-synuclein seed amplification assay (SAA) status.…White Matter Abnormalities in Progressive Supranuclear Palsy (PSP) vs. Parkinson’s Disease (PD): Evaluation with a Convolutional Neural Network (CNN)-Based Tool
Objective: This study aimed to compare white matter hyperintensity (WMH) burden between PSP and PD using a novel AI-based tool for more accurate WMH volume…
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