Longitudinal free-water changes in dementia with Lewy bodies
Objective: To characterize longitudinal diffusion microstructural changes in individuals with dementia with Lewy bodies (DLB). Background: Diffusion-weighted MRI (dMRI) examines tissue microstructure integrity in vivo.…An investigation of early changes in the brain due to mild cognitive impairment in Parkinson’s disease
Objective: To identify baseline structural brain differences between individuals with Parkinson's disease (PD) who go on to develop mild cognitive impairment (PD-MCI) and those who…Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients
Objective: To investigate the association between cerebrospinal (CSF) αS aggregates, MRI, and dopamine transporter spectral tomography (DaTscanTM) imaging metrics. Background: Synuclein amplification assays (SAA) enables…An in-vivo study of the integrity of the nigrostriatal pathways in drug-naive Parkinson’s disease patients using [11C]PE2I PET and neuromelanin-Magnetic Resonance Imaging
Objective: This study evaluated the relationship between the neurodegeneration of the substantia nigra neurons, assessed using Neuromelanin-sensitive MRI, and of the loss of striatal dopaminergic…Diabetic striatopathy presenting without hyperkinetic movements
Objective: To demonstrate a case of Diabetic striatopathy presenting without hyperkinetic movements Background: Diabetic striatopathy is an uncommon neurological complication associated with poorly controlled Diabetes Mellitus…Does hyposmia induce apathy in early Parkinson’s disease? Lessons from structural brain connectivity
Objective: To study changes in microstructural integrity of white matter tracts associated with apathy in patients with early Parkinson’s disease (PD) and hyposmia Background: Smells…Neurogenic Orthostatic Hypotension in Parkinson’s Disease: Is there a role for Locus Coeruleus Magnetic Resonance Imaging?
Objective: To test whether degeneration of the Locus Coeruleus (LC) is associated with Orthostatic Hypotension (OH) in Parkinson’s disease (PD).To test whether degeneration of the…Altered nucleus accumbens functional connectivity precedes apathy in Parkinson’s disease
Objective: To investigate whether changes in connectivity between neural regions that are associated with goal-directed behaviour predict future development of apathy in people with Parkinson’s…Is working memory training success in Parkinson’s disease determined by cortical thickness and white matter lesions?
Objective: We aimed to evaluate the influence of cortical thickness (CT) and white matter lesions (WML) on working memory training (WMT) success in cognitively unimpaired…Agreement between swallow tail sign asymmetry and clinical laterality in Parkinson’s disease
Objective: Our goal was to evaluate the concordance between asymmetry in nigral hyperintensity detected with 3T MRI and clinical symptomatology. Background: A promising MRI marker…
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