7 Tesla MRI with Quantitative Susceptibility Mapping: Quantitative focal measurements and qualitative grading of the substantia nigra as a biomarker for Parkinson’s Disease
Objective: To quantitatively and qualitatively evaluate susceptibility changes in the dorsal SN (dSN), using quantitative susceptibility mapping (QSM) and susceptibility-weighted imaging (SWI) at 7Tesla (7T)…Basal Ganglia Lacunar Infarcts and Risk of Mortality and Dementia in Parkinsonism: A Population-Based Study
Objective: To determine the prevalence of chronic basal ganglia lacunar infarcts (BGLI) and examine their association with dementia and mortality in a population-based cohort of…Remaining unmet needs in Essential Tremor and Parkinson’s Disease: European Neurologists’ Assessments of Pharmacologic Response and Advanced Therapy Use
Objective: To investigate neurologists’ perceptions of treatment effectiveness and criteria for selecting patients for advanced therapies in essential tremor (ET) and Parkinson’s disease (PD). Background:…Differential Cholinergic White Matter Microstructural Alterations in Multiple System Atrophy and Parkinson’s Disease
Objective: To investigate the extent and pattern of microstructural alterations of cholinergic pathways in MSA and PD. Background: MSA and PD are both α-synucleinopathies with…A Diffusion MRI Neurodegeneration Index for Lewy Body Dementia & Alzheimer’s disease
Objective: To develop a diffusion MRI-based neurodegeneration index using free-water imaging and assess its ability to quantify neurodegenerative burden in Lewy body dementia (LBD) and…Redefining Anatomical Boundaries, An Atypical Case of MV-PLUS with Supratentorial extension.
Objective: To report the first case of Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance (MV-PLUS) with atypical supratentorial temporal extension, expanding the known…The utility of HbA1c in Predicting Neuroimaging Findings in Diabetic Striatopathy – A Systematic Review
Objective: To explore the impact of HbA1c on imaging in Diabetic Striatopathy. Background: Diabetic Striatopathy (DS) is a rare neurological complication of hyperglycemia. While glycemic…PET Imaging of Presynaptic Terminals with [18F]SynVesT-1 in Premanifest Huntington’s Disease
Objective: To assess synapse loss in vivo in late premanifest Huntington’s disease (HD) subjects using [18F]SynVesT-1 positron emission tomography (PET). Background: Synaptic damage is believed…Comparison of Neuroimaging-Derived and Clinical Motor Subtypes in Early Parkinson’s Disease
Objective: To evaluate diffusion MRI-derived extracellular free water (isotropic diffusion [ISO]) in subcortical motor regions and compare data-driven ISO-based subtypes with clinically defined tremor-dominant (TD),…Peak Mean Skeletal Diffusivity as a Marker of Cognitive Impairment in Parkinson’s disease
Objective: To determine whether the Peak width of Skeletonised Mean Diffusivity (PSMD), an automated diffusion MRI–derived marker of white matter microstructural integrity, differs between individuals…
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