Locus Coeruleus-Thalamic Circuit Degeneration in Parkinson’s Disease
Objective: This study characterizes the microstructural evolution of the locus coeruleus (LC) and its thalamic projection tract in Parkinson’s disease (PD) using free‑water imaging across…Clinical Significance of Automatically Assessed Perivascular Space Count in Subcortical White Matter of Parkinson’s Disease
Objective: This study aimed to examine the relationship between automatically quantified perivascular space (PVS) count located in the subcortical white matter (WM), baseline motor deficits,…Microstructure predicts cognition after Neurostimulation in Parkinson’s disease
Objective: To identify preoperative microstructural markers that are associated with postoperative changes in cognition. Background: Subthalamic deep brain stimulation (STN-DBS) represents an established therapeutic intervention…Plasma p-tau217 outperforms p-tau181 as a biomarker of Alzheimer’s disease co-pathology in the Lewy Body Disorders spectrum
Objective: To evaluate the relative performance of plasma p-tau217 and p-tau181 as biomarkers of Alzheimer’s disease (AD) co-pathology across the Lewy body disorders (LBD) spectrum.…DTI-Based Comparative Analysis of Microstructural Alterations in Parkinson Disease and Atypical Parkinsonism
Objective: Diffusion tensor imaging (DTI) holds promising potential for investigating pathological changes in white matter (WM). In recent years, numerous studies worldwide have demonstrated that…7 Tesla MRI with Quantitative Susceptibility Mapping: Quantitative focal measurements and qualitative grading of the substantia nigra as a biomarker for Parkinson’s Disease
Objective: To quantitatively and qualitatively evaluate susceptibility changes in the dorsal SN (dSN), using quantitative susceptibility mapping (QSM) and susceptibility-weighted imaging (SWI) at 7Tesla (7T)…Basal Ganglia Lacunar Infarcts and Risk of Mortality and Dementia in Parkinsonism: A Population-Based Study
Objective: To determine the prevalence of chronic basal ganglia lacunar infarcts (BGLI) and examine their association with dementia and mortality in a population-based cohort of…Remaining unmet needs in Essential Tremor and Parkinson’s Disease: European Neurologists’ Assessments of Pharmacologic Response and Advanced Therapy Use
Objective: To investigate neurologists’ perceptions of treatment effectiveness and criteria for selecting patients for advanced therapies in essential tremor (ET) and Parkinson’s disease (PD). Background:…Differential Cholinergic White Matter Microstructural Alterations in Multiple System Atrophy and Parkinson’s Disease
Objective: To investigate the extent and pattern of microstructural alterations of cholinergic pathways in MSA and PD. Background: MSA and PD are both α-synucleinopathies with…A Diffusion MRI Neurodegeneration Index for Lewy Body Dementia & Alzheimer’s disease
Objective: To develop a diffusion MRI-based neurodegeneration index using free-water imaging and assess its ability to quantify neurodegenerative burden in Lewy body dementia (LBD) and…
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