Activation of the MT1 Receptor Ameliorates Mitochondrial Dysfunction in MPP+/MPTP-Induced Parkinson’s Disease
Objective: This study aimed to explore the role of melatonin receptor 1 (MT1) in improving mitochondrial dysfunction in MPP⁺/MPTP-induced PD models and to clarify the…Midbrain Organoid Modeling and Transcriptomic Characterization of NOTCH2NLC GGC Repeat Expansion–Associated Parkinson’s Disease
Objective: To characterize transcriptomic alterations in patient-derived midbrain organoids carrying NOTCH2NLC GGC repeat expansions and assess their relevance to canonical Parkinson's disease (PD) mechanisms. Background:…Adolescent-onset Myoclonus Dystonia in MT-ND6 m.14487T>C–Associated Leigh Syndrome
Objective: To describe the clinical and genetic features of an adolescent patient with MT-ND6-associated Leigh syndrome presenting with a prominent dystonia and myoclonus. Background: Leigh…Mitochondrial Density Shapes Regional Vulnerability to Atrophy in Parkinson’s Disease
Objective: To characterise the coupling between regional mitochondrial density and complex I activity and spatially patterned brain atrophy in Parkinson's disease (PD), and its variation…Targeting c-Abl/Drp1-Dependent Mitochondrial Fission: Neuroprotective Effects of Berberine Chloride in Parkinson’s Disease Models
Objective: To investigate the neuroprotective potential of berberine chloride in Parkinson’s disease (PD) by modulating pathological mitochondrial fission through c-Abl–mediated Drp1 phosphorylation using integrated bioinformatics,…Association of MT-ATP6 Polymorphisms with Increased Reactive Oxygen Species and Biomarker Alterations in Parkinson’s Disease
Objective: To evaluate the association between MT-ATP6 gene polymorphisms, oxidative stress, and biomarker alterations in PD patients from Indian populaiton Background: Mitochondrial dysfunction and oxidative…SNCA Dysregulation Drives Oxidative Stress and Mitochondrial Dysfunction in Parkinson’s Disease: Evidence from a Punjab Cohort
Objective: This study aimed to investigate SNCA gene alterations alongside oxidative stress and mitochondrial dysfunction in early-onset PD (EOPD) and late-onset PD (LOPD) subjects from the Punjab…Translational Target Engagement of HER-096 Demonstrates Concordant Proteostasis and Mitochondrial Modulation in Preclinical Models and Patients with Parkinson’s Disease
Objective: To evaluate translational target engagement of HER-096, a CDNF-derived peptidomimetic, in preclinical models of Parkinson’s disease (PD) and in a Phase 1b clinical study…PPAR-γ-dependent Neuroprotection by Ferulic acid improves Motor deficits in 3-nitropropionic acid model of Huntington’s disease in rats
Objective: This study investigates the neuroprotective role of FA in 3-nitropropionic acid (3-NP) model of HD through PPAR-γ–mediated mechanisms. Background: Huntington disease (HD) is a…Investigating Mitochondrial Integrity in Spinocerebellar Ataxia Type 12 via Patient-Derived iPSC Models
Objective: This study aims to establish patient-derived induced pluripotent stem cell (iPSC) models of Spinocerebellar Ataxia Type 12 (SCA12) and investigate mitochondrial transcriptional alterations across…
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