MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Mitochondrial dysfunction"

  • 2024 International Congress

    Parkinson’s disease associated SORL1 variants impair mitochondrial and endo-lysosomal function

    Z. Liu, M. Zhao, Y. Zhao, J. Tan, B. Tang (Changsha, China)

    Objective: We investigate the relationship between Sortilin-related receptor (SORL1) gene and PD, along with their functional implications. Background: Parkinson's disease (PD) is a common neurodegenerative…
  • 2024 International Congress

    The Effect of an Exogenous Ketone Supplement on Gut Microbiota in Parkinson’s disease, a Pilot Study

    V. Vedam-Mai, M. Beke, V. Mai, P. Mackie, E. Klann, A. Gurrala, S. Chua, E. Ince, L. Almeida, A. Ramirez-Zamora (Gainesville, USA)

    Objective: To investigate the effect of exogenous oral ketone esters on gut microbiota in people with PD. Background: Mitochondrial dysfunction in the substantia nigra and…
  • 2024 International Congress

    A Patient with Overlapping SPG7 mutation and MERRF

    J. Patino, M. Koenig (Houston, USA)

    Objective: To describe the first case of concomitant spastic paraplegia type 7 (SPG7) and myoclonic epilepsy with ragged red fibers (MERRF) in a patient with…
  • 2024 International Congress

    Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO), A Novel Retinal Mitochondrial Biomarker For Parkinson’s Disease

    K. Shivok, E. Affel, M. Alizadeh, T-W. Liang, D. Kremens, R. Sergott (Philadelphia, USA)

    Objective: Using fluorescence-lifetime ophthalmoscopy (FLIO), we identified retinal mitochondrial changes in Parkinson’s disease (PD) patients compared to controls. Background: FLIO, a novel non-invasive, in vivo…
  • 2024 International Congress

    Phenotypic variability of mitochondrial tRNA Ser(UCN) gene [MTTS1] mutation: First report from India

    N. Pandita, J. Ganguly, P. Basu, N. Singh, S. Mukherjee, H. Kumar (Kolkata, India)

    Objective: To describe a rare cause of mitochondrial ataxia in an Indian Agarwal family, associated with cytochrome c oxidase deficiency due to point mutation in…
  • 2024 International Congress

    GPR30 agonists attenuate haloperidol-induced neurotoxicity in SH-SY5Y cells and adult zebrafish.

    SHU. Upadhayay, PKB. Kumar (Baathinda, India)

    Objective: Objective:1. To investigate the neuroprotective effect of FDA-approved compounds (Raloxifene and Fulvestrant) against haloperidol-induced neurotoxicity in SHSY-5Y cells and adult zebrafish2. To explore the molecular…
  • 2024 International Congress

    PMM2 mutation

    H. Teive, J. Duarte, LE. de Farias, S. Raskin, F. Tensini, D. Amarante (Curitiba, Brazil)

    Objective: describe glycosylation type 1A PMM2 mutation presented as motor development regression and cognitive impairment proving to be a disease that should’ve been detected precociously.…
  • 2024 International Congress

    Neuroprotective Action of Betulin in Parkinson’s disease: Alleviating Mitochondrial Dysfunction and Oxidative Stress-Induced Apoptosis in rat model

    A. Kumar (Allahabad, India)

    Objective: The objective of this study was to evaluate the neuroprotective efficacy of Betulin in MPTP-induced mice models of Parkinson's disease (PD), focusing on its…
  • 2024 International Congress

    Targeting miR-27 with Antisense Oligonucleotides for Disease Modification in Parkinson’s Disease

    L. Ponsati, S. Hansen, M. Scharff, H. Klitgaard, S. Kauppinen, E. Bezard, J. Erler (København SV, Denmark)

    Objective: Achieve disease modification in idiopathic Parkinson’s Disease through miR-27 targeting using Antisense Oligonucleotides Background: There are currently no disease-modifying therapies for Parkinson’s Disease (PD).…
  • 2023 International Congress

    In vitro α–synuclein aggregation and propagation model

    F. Kapucu, I. Tujula, O. Kulta, L. Sukki, V. Vuolanto, A. Vinogradov, P. Kallio, S. Narkilahti (Tampere, Finland)

    Objective: Developing an in vitro α–synuclein (α-s) aggregation and propagation model of human cortical networks for functionality studies. Background: Studying α–s pathology and its effects…
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