Parkin regulates ER-mitochondria association through interaction with IP3R-Grp75-VDAC1
Objective: The objective of this study is to explore how Parkin modulates the interplay between mitochondria and the endoplasmic reticulum (ER), along with elucidating its…iPLA2β controls ER-mitochondria tethering and Ca2+ transfer in Parkinson’s disease
Objective: In this study, we aimed to investigate whether Parkinson's disease (PD) associated calcium-independent phospholipase A2β (iPLA2β) regulates the integrity and functions of endoplasmic reticulum…A novel single-cell reporter identifies regulators of the endogenous PINK1-Parkin mitochondrial quality control pathway
Objective: We aimed to identify genome-wide regulators of the PINK1-Parkin pathway using a novel flow cytometry reporter, endogenously tagged MFN2, as a readout of the…Age- and Sex-Associated Changes in the Behavior of Neuronal Mitochondria During Healthy Aging
Objective: To determine age-associated changes in the size, density, movement, and dynamics of mitochondria as a function of sex, using microRNA-induced neurons derived from primary…Measures of Mitochondrial Function in Serum across the Parkinson’s Disease Spectrum
Objective: To resolve the inconsistencies in the magnitude and type of mitochondrial dysfunction within peripheral blood mononuclear cells (PBMCs) from people with Parkinson’s disease (PD),…Alpha-Synuclein and Mitochondria Quality Control in Parkinson’s Disease: A Literature Review
Objective: To provide an overview of the current knowledge on alpha-synuclein (αS) interactions with mitochondrial quality control (MQC) pathways in Parkinson’s disease (PD). Background: The…Mitochondrial Complex I Brain Imaging in Parkinson’s Disease and Lewy Body Dementia
Objective: To compare brain mitochondrial respiratory Complex-1 (mito-C1) between Parkinson’s disease (PD) and PD dementia/Dementia with Lewy Bodies (PDD/DLB) participants and unimpaired controls, using 18F-BCPP-EF,…Cardiac Mitochondrial Complex I Integrity Predicts Axial Symptom Severity in Parkinson’s Disease
Objective: In the present work, we investigated whether cardiac mitochondrial dysfunction might also be associated with the severity of PIGD symptoms in PD patients. Background:…Utility of Whole Exome Sequencing in movement disorders potentially related to Mitochondrial cytopathies
Objective: To describe the clinic-genetic profile of clinically suspected mitochondrial cytopathies with movement disorders (MDs). Background: Literature on the clinico-genetic spectrum of movement disorders related…Parkinson’s disease associated SORL1 variants impair mitochondrial and endo-lysosomal function
Objective: We investigate the relationship between Sortilin-related receptor (SORL1) gene and PD, along with their functional implications. Background: Parkinson's disease (PD) is a common neurodegenerative…
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