Comparative Effectiveness of Tavapadon Versus Real-world Oral Standard of Care Treatments in Parkinson’s Disease With Motor Fluctuations: an Indirect Comparison Analysis
Objective: To compare clinical-trial tavapadon with real-world oral standard of care (SoC) in patients with Parkinson’s disease (PD) experiencing motor fluctuations. Background: In the phase…Prosodic speech variability is associated with speech-related stigma in Parkinson’s disease
Objective: To investigate whether objective acoustic speech parameters are associated with perceived speech-related stigma in Parkinson’s disease (PD). Background: Speech impairment is common in PD…Levodopa Initiation in Phase 3 Trials of Tavapadon, a Selective D1/D5 Agonist for Early Parkinson’s Disease
Objective: To evaluate motor improvements in adults with early Parkinson’s disease (PD) who initiated levodopa (LD) during phase 3 trials of tavapadon. Background: Tavapadon, an…PLIC Fractional Anisotropy and Motor Outcome After Functional Neurosurgical Treatment in Parkinson’s Disease
Objective: To assess whether microstructural integrity of the posterior limb of the internal capsule, measured by diffusion MRI fractional anisotropy, is associated with motor outcome…Fusion Learning with Attention-VAE Imputation for Mixed-Reality Multisensor Screening of Parkinson’s Disease
Objective: To evaluate whether a mixed-reality (MR) multisensor protocol combined with multimodal learning can discriminate Parkinson’s disease (PD) from healthy controls (HC) despite substantial missing…Oral D1-like/D2-like Receptor Agonist, Lu AF28996, Provides Robust Antiparkinsonian Efficacy with Reduced Dyskinesia in the MPTP-Macaque Model
Objective: Evaluate the therapeutic potential of Lu AF28996 in the MPTP-macaque model of PD. Background: Chronic levodopa treatment is associated with the development of motor…Objective Parkinson’s Diagnosis Using a Novel Accelerometer Assessment and Machine Learning
Objective: To evaluate a novel motor assessment using a handheld accelerometer and machine learning to objectively support Parkinson's disease (PD) diagnosis. Background: PD diagnosis is…Speaking in Noise: Examination of Speech Motor Control in Parkinson’s Disease
Objective: This study aims to investigate the relationship between background noise and a speech scaling task in individuals with Parkinson’s disease to better understand speech…A Meta-analysis of Tonic Motor Activation (TOMAC) Therapy for Restless Legs Syndrome
Objective: To evaluate the efficacy and safety of Tonic Motor Activation (TOMAC) therapy for adults with restless legs syndrome (RLS). Background: TOMAC is a novel,…Lu AF28996, a Novel Oral D1-like/D2-like Receptor Agonist, May Improve Motor Complications in People with Parkinson’s Disease: Results from an 18-week open-label, Phase 1b Trial
Objective: Evaluate safety, tolerability, and clinical effects of Lu AF28996 in patients with inadequately controlled advanced Parkinson’s disease (PD) experiencing motor fluctuations, with or without…
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