Multimodal Immune Biomarkers of Parkinson’s Disease Progression
Objective: To determine the longitudinal relationship between immune parameters and Parkinson’s progression; and immune predictors of motor and cognitive milestones. Background: PD progression is highly…Efficacy of Mechanoacoustic Vibration Therapy on Motor Function, Bone Density, and Sleep Architecture in Elderly Women with Restless Legs Syndrome
Objective: To evaluate the rehabilitative impact of targeted mechanoacoustic vibration therapy on mobility, bone mineral density (BMD), pain, and sleep quality in elderly women with…Consistent Motor Benefit of Safinamide across Clinically Relevant Subgroups in Japanese Patients with Parkinson’s Disease: A 24-Week Real-World Study
Objective: To evaluate changes in motor symptoms after safinamide initiation in Japanese patients with Parkinson’s disease (PD) in real-world clinical practice. Background: Safinamide, a monoamine…Machine Learning for Early Detection of Huntington’s Disease: Integrating Non-Motor Symptoms and Gender-Specific Differences
Objective: To develop a machine learning (ML) model for early Huntington’s disease (HD) detection by integrating non-motor symptoms (NMS) and DNA methylation patterns, leveraging gender-specific…Restoring the Axis: Efficacy of Fecal Microbiota Transplantation (FMT) on Motor and Non-Motor Symptoms in Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2023–2025)
Objective: To methodically assess the safety and effectiveness of fecal microbiota transplantation (FMT) in comparison to a placebo for Parkinson's disease (PD) patients' motor and…Why Context Matters: The Influence of Medication and Environment on Real-World Gait in People with Parkinson’s Disease
Objective: To quantify the extent to which contextual factors explain the variability in real-world gait outcomes in people with Parkinson’s disease (PwP) using machine learning…Retrospective Video-Based Motor Assessment: Feasibility and Inter-Rater Variability in Remote Scoring
Objective: To assess the feasibility of extracting video-derived motor biomarkers from retrospective clinical recordings in Parkinson's disease (PD) and quantify agreement with clinician-rated MDS-UPDRS Part III item…The “Guarda” (Tower) Drawing Test: A Novel Bedside Tool to Quantify Bradykinesia in Parkinson’s Disease
Objective: Quantify Bradykinesia Through Standardized Drawing in PD patients. Background: Bradykinesia is the cardinal symptom in Parkinson's Disease (PD). The slowing and progressive reduction in…Automated Identification of Freezing of Gait in Parkinson’s Disease Using Q-Learning Analysis during Virtual Reality–Based Gait Task
Objective: To investigate whether a virtual reality (VR)-based gait task can induce freezing of gait (FOG) in Parkinson’s disease (PD) and whether gait trajectory data…Early Descriptions of Sensorimotor Control and Movement Disorders in the Medieval Islamic Golden Age: Insights from Rhazes (Al Razi) and Avicenna (Ibn Sina)
Objective: To examine the historical scientific contributions of Rhazes and Avicenna and investigate their approach towards sensorimotor control and movement disorders. Background: Medieval Persia has…
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