Lu AF28996, a Novel Oral D1-like/D2-like Receptor Agonist, May Improve Motor Complications in People with Parkinson’s Disease: Results from an 18-week open-label, Phase 1b Trial
Objective: Evaluate safety, tolerability, and clinical effects of Lu AF28996 in patients with inadequately controlled advanced Parkinson’s disease (PD) experiencing motor fluctuations, with or without…Associations Between Saccadic and Motoric Symptoms in Parkinson’s Disease
Objective: To explore associations between saccadic measures and i) global motor, ii) non-tremor motor, and iii) tremor severity in Parkinson’s disease (PD). Background: Impaired voluntary…Cerebellar-cortical-spinal information flow for motor kinematic control
Objective: If M1 generates final motor outputs and cerebellar temporal kinematic information must pass through M1, then M1 should relay cerebellar frequency codes to the…Impaired Retention of Goal-Directed Movements in Parkinson’s Disease: A 2-Year Longitudinal Analysis
Objective: Many uncertainties remain regarding the motor learning challenges faced by individuals with PD, specifically in retaining and recalling acquired motor skills over time without…DCN-PPN Pathway Activation Improves Motor Dysfunction via Synaptic Plasticity in Parkinson’s Disease
Objective: To define the anatomical and functional connectivity of the DCN-PPN pathway, determine its alterations in PD, and investigate whether impaired synaptic plasticity in this…Movement decoding from subthalamic nucleus during deep brain stimulation surgery
Objective: To evaluate motor classification and somatotopy of local field potentials (LFPs) recorded from subthalamic nucleus (STN) directional deep brain stimulation (DBS) electrodes. Background: STN…Biological Predictors of Clinical Domains in Isolated REM Sleep Behavior Disorder with and without Synucleinopathy and Dopamine Dysfunction
Objective: To determine if baseline biomarkers predict baseline and progression of clinical domains in isolated REM sleep behavior disorder (iRBD). Background: iRBD has high conversion…Aerva Lanata Decoction Alleviates Neuroinflammation And Locomotor Dysfunction In Parkinson Model
Objective: The study focussed on the protective effects of decoction of aerial parts of the Aerva lanata against neuroinflammation, oxidative stress and locomotor deficits against…Wearable-Derived Cardiac Features and Cardiac–Motor Interconnection Across Parkinson’s Disease Severities
Objective: To examine how wearable-derived cardiac performance and cardiac–motor interconnection (CCM) vary across Parkinson’s disease (PD) severities, stratified by the Parkinson’s disease–cognitive rating scale (PD-CRS)…Treadmill-Based Backward Walking Training as a Rehabilitation Strategy in People with Parkinson’s Disease: A Feasibility Study
Objective: To evaluate the feasibility of treadmill-based backward walking training in people with Parkinson’s disease(PwPD) Background: Parkinson’s disease(PD) is a progressive neurodegenerative disorder characterized by…
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