A Phase II Randomized, Parallel, Double-blind, Placebo-controlled Study of the Efficacy and Safety of WD-1603 in Subjects with Parkinson’s Disease
Objective: To investigate the effectiveness, safety and pharmacokinetics of WD-1603 carbidopa-levodopa controlled-release tablets in subjects with Parkinson's disease. Background: The development of drug products that…Brain hemodynamic responses to a motor control paradigm in younger and older adults, and people with Parkinson’s Disease: An fNIRS mediated feasibility study.
Objective: This study aims to investigate the use of fNIRS in measuring the hemodynamic response of the brain during motor control tasks of increasing complexity…Yawning Associated Parakinesia Brachialis Oscitans, Penile Erection, and Truncal Seizures Following Intracerebral Hemorrhage
Objective: To describe a rare case of parakinesia brachialis oscitans (PBO) with yawning-associated penile erection and truncal seizures in a patient with a right middle…Cognitive Load Modulates Excitability of Subthalamic Motor Circuitry in Parkinson’s Disease
Objective: To characterize the effect of cognitive load on the excitability of circuitry connected with the subthalamic nucleus (STN) motor territory in Parkinson’s disease (PD)…Prevalence and Characteristics of Glucocerebrosidase Genetic Variants in Nepalese Early-onset Parkinson’s Disease Patients
Objective: To evaluate the genotype and phenotype of early-onset Parkinson´s Disease (EOPD) in the Nepalese population. Background: A significant proportion of early-onset PD (EOPD) can…The cerebellum encodes dynamic motor frequencies for volitional movements
Objective: Investigate how the cerebellum computes and regulates motor precision during daily movements Background: Motor coordination, ensuring movement precision and reliability, is governed by the…Does the cerebellum compensate to enable motor learning in Parkinson’s Disease?
Objective: To test the causal relation between cerebellar function and learning in PD. Background: Neuroimaging studies reveal that people with Parkinson’s disease (PwPD) exhibit increased…Local field potential vs image guided programming: clinical trial for optimization the deep brain stimulation in Parkinson’s disease
Objective: To determine the most effective and efficient STN-DBS programming method in PD comparing LFP-GP and IGP focusing on motor improvement, quality of life and…Observations and Strategies for Improving Recruitment and Retention of Underrepresented Populations in Movement Disorders Clinical Research Trials Conducted in a Tertiary Research Site
Objective: To observe the improvement in one tertiary clinical site of the recruitment of underrepresented populations with a focus on the Asian demographic and note…Sustained Motor Symptom Efficacy With Long-Term Levodopa–Entacapone–Carbidopa Intestinal Gel (LECIG) Treatment – Data From The ELEGANCE Interim Analysis
Objective: To evaluate the long-term effect on motor symptoms of advanced Parkinson’s disease (PD) following up to two years of treatment with LECIG by analysis…
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