Impulse Control in Parkinson’s: β- and Muscle Burst Dynamics Reveal Distinct Effects of Pathology and Dopamine Medication
Objective: To examine β- and muscle bursting patterns during impulse control in medicated and non-medicated people with Parkinson's disease (PwPD) to disentangle effects of disease…Changes in Continuous Good ON and Best ON Time During the Waking Day With Tavapadon in People With Parkinson’s Disease
Objective: To evaluate motor states throughout the waking day when tavapadon is added to oral carbidopa/levodopa in adults with Parkinson’s disease (PD) experiencing motor fluctuations.…Comparative Effectiveness of Tavapadon Versus Real-world Oral Standard of Care Treatments in Parkinson’s Disease With Motor Fluctuations: an Indirect Comparison Analysis
Objective: To compare clinical-trial tavapadon with real-world oral standard of care (SoC) in patients with Parkinson’s disease (PD) experiencing motor fluctuations. Background: In the phase…Prosodic speech variability is associated with speech-related stigma in Parkinson’s disease
Objective: To investigate whether objective acoustic speech parameters are associated with perceived speech-related stigma in Parkinson’s disease (PD). Background: Speech impairment is common in PD…Levodopa Initiation in Phase 3 Trials of Tavapadon, a Selective D1/D5 Agonist for Early Parkinson’s Disease
Objective: To evaluate motor improvements in adults with early Parkinson’s disease (PD) who initiated levodopa (LD) during phase 3 trials of tavapadon. Background: Tavapadon, an…PLIC Fractional Anisotropy and Motor Outcome After Functional Neurosurgical Treatment in Parkinson’s Disease
Objective: To assess whether microstructural integrity of the posterior limb of the internal capsule, measured by diffusion MRI fractional anisotropy, is associated with motor outcome…Fusion Learning with Attention-VAE Imputation for Mixed-Reality Multisensor Screening of Parkinson’s Disease
Objective: To evaluate whether a mixed-reality (MR) multisensor protocol combined with multimodal learning can discriminate Parkinson’s disease (PD) from healthy controls (HC) despite substantial missing…Oral D1-like/D2-like Receptor Agonist, Lu AF28996, Provides Robust Antiparkinsonian Efficacy with Reduced Dyskinesia in the MPTP-Macaque Model
Objective: Evaluate the therapeutic potential of Lu AF28996 in the MPTP-macaque model of PD. Background: Chronic levodopa treatment is associated with the development of motor…Objective Parkinson’s Diagnosis Using a Novel Accelerometer Assessment and Machine Learning
Objective: To evaluate a novel motor assessment using a handheld accelerometer and machine learning to objectively support Parkinson's disease (PD) diagnosis. Background: PD diagnosis is…Speaking in Noise: Examination of Speech Motor Control in Parkinson’s Disease
Objective: This study aims to investigate the relationship between background noise and a speech scaling task in individuals with Parkinson’s disease to better understand speech…
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