Drivers of Navigated Walking Performance in Aging and Parkinson’s Disease: Insights From Behavioral Clustering, Clinical and Neuroimaging Data
Objective: Identify and characterize patterns of navigated walking performance in people with PD (Parkinson’s disease) and healthy adults, by means of data-driven cluster analysis. Background:…Toward Objective Monitoring of Motor Fluctuations in Parkinson’s Disease: TMS-EEG Biomarkers
Objective: Assess utility of TMS-EEG as objective markers for Motor fluctuations (MF) in Parkinson’s disease (PD). Background: MF in PD are episodic changes in motor…Adaptive Deep Brain Stimulation in Parkinson Disease: Preliminary Single-Center Results
Objective: To describe initial outcomes of alpha-beta (8-30Hz)-guided subthalamic nucleus (STN) adaptive deep brain stimulation (aDBS) in Parkinson disease (PD) in a single-center cohort. Background:…Objective profiling of parkinsonian and essential tremor using EMG and accelerometry
Objective: To determine whether electrophysiological features derived from EMG and accelerometry can distinguish PD tremor from ET. Background: Clinical differentiation between tremor in Parkinson’s disease…Burst versus Conventional Deep Brain Stimulation Engage Distinct Cortico-Subthalamic Circuit Dynamics in Parkinson’s Disease
Objective: To characterize the neural effects of burst DBS (bDBS) on cortico-subthalamic circuit dynamics in Parkinson’s disease (PD) and determine whether they differ from conventional…A Novel paradigm for the recording of col-cap movements and muscle activity in Cervical Dystonia
Objective: We developed a protocol combining multi-muscle surface electromyography (sEMG) and kinematic analysis to characterise cervical muscle activity and head-neck-trunk movement patterns in CD after…Serum Biomarker Profiles in Adolescents with Type 1 Diabetes-Associated Dystonia: The Role of Neurofilament Light Chain and Metabolic Indices
Objective: To evaluate the relationships between serum neurofilament light chain (NfL), homocysteine (Hcy), glycated hemoglobin (HbA1c), folic acid, and vitamin B12, and their impact on…Evaluation of Electromyographic Measures of Cervical Dystonia Using a 12-Muscle Recording Paradigm
Objective: We evaluated the presence of these features across a set of 12 cervical muscles predominantly associated with abnormal posturing in CD using a multi-muscle…Data Driven Clinical Insights from Longitudinal Cloud-Aggregated Neural Data to Inform a Real-World Adaptive DBS Programming
Objective: Characterize clinical workflow insights gained from expanded access to neural data via a cloud connected platform in adaptive DBS. Background: Adaptive deep brain stimulation…Intranasal Delivery of Berberine-Loaded Solid Lipid Nanoparticles Ameliorates Neuropathological and Behavioral Deficits in a Preclinical Alzheimer’s Model
Objective: To evaluate the pharmacokinetic profile and neuroprotective efficacy of intranasally administered berberine-loaded solid lipid nanoparticles (BE-SLN) in a streptozotocin (STZ)-induced rat model of Alzheimer’s…
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