Comparison of LFP-physiomarkers for DBS programming
Objective: To evaluate clinical usability of LFP(local field potentials)-physiomarkers and lead localisation for selection of suitable DBS electrode configurations. Background: Selection of optimal contacts in…Muscle Ultrasound Comparison Between Early And Intermediate Onset Friedreich’s Ataxia
Objective: Background: Early-onset Friedreich’s Ataxia (FA) concerns a classic pediatric phenotype (p-FA, starting before 18 years of age), characterized by relentlessly progressive ataxia and (cardio)myopathy.…Movement and postural control in focal dystonia subjects measured using surface electromyography
Objective: To explore the difference in muscle activation during a postural versus movement control task in patients with focal dystonia. Background: Co-contraction of agonist and…Temporal discrimination threshold in musician’s dystonia – an endophenotype?
Objective: To compare the temporal discrimination threshold (TDT) between musician's dystonia (MD) patients and healthy controls, and between dystonic and non-dystonic fingers of musicians with…Local field potential changes during sleep in the PSA of patients with essential tremor
Objective: To investigate changes in local field potential (LFP) activity of the posterior subthalamic area (PSA) in patients with essential tremor (ET) during wakefulness and…The utility of electrophysiological tests in the differentiation of upper limb tremor in young-onset patients
Objective: To explore the diagnostic utility of neurophysiologic tests in young-onset patients who present primarily with upper limb action tremor. Background: In young-onset patients, isolated…Closed loop spinal cord stimulation restores locomotion and desynchronizes corticostriatal beta oscillations
Objective: To test if closed loop Spinal Cord Stimulation (SCS) could be used to restore locomotion in a 6-hydroxydopamine (6-OHDA ) rodent model of Parkinson's…Long-term and dopamine dependent dynamics of subthalamic nucleus local field potentials in Parkinson’s disease
Objective: Using a new deep brain stimulation (DBS) pulse generator device that can record local field potentials (Activa PC+S, Medtronic Inc.), the current experiment investigated…Remote patient monitoring with a digital biomarker approach generates clinically distinctive and meaningful sensor feature data in Parkinson’s disease: Differential relationships with MDS-UPDRS-III, PDQ-39 and DaT-SPECT
Objective: To determine whether sensor features derived from remote smartphone testing in Parkinson’s disease (PD) predicted clinical, quality of life and biomarker measures collected in…Evaluation of bradykinesia in Parkinson’s disease using a computerised evolutionary algorithm
Objective: Application of a computerised algorithm to kinematic motor recordings to distinguish parkinsonian bradykinesia from normal movement. Background: Bradykinesia, the only obligatory physical sign for…
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