Investigating the role of microRNA biogenesis pathway in neuroprotection in primary neuronal culture model of Parkinson’s disease
Objective: Here we study the effect of microRNAs (miRs) biogenesis on the dopamine (DA) neuronal maintenance and protection from different stressor-induced insults. Background: Despite many…Ginsenoside Rb1 protects dopaminergic neurons through Foxm1-Nurr1 pathway in mice model of Parkinson’s disease
Objective: In the present work, we investigated the protective effects of ginsenoside Rb1 in dopaminergic neurons through Foxm1-Nurr1 pathway in mice model of Parkinson’s disease.…Neuromodulatory properties of flavonoids from Persea americana Peel: Role in CNS redox homeostasis and neurobehavioral markers
Objective: Isolating flavonoids from Peel of Persea americana fruits & testing their effects on CNS redox homeostasis culminating in neurobehavioural amelioration among rats. Background: Cellular…Neuromodulatory propensity of Ginko biloba to offset rotenone induced behaviour and biochemical alteration
Objective: The aim of present study was to evaluate neuromodulatory propensity of Gingko Biloba in rotenone induced Mice Model of Parkinson Disease in terms of…Rotigotine protects dopaminergic neurons by targeting serotonin 1A receptors on astrocytes
Objective: In this study, we examined neuroprotective effects of rotigotine and involvement of serotonin 1A (5-HT1A) receptors on astrocytes in neuroprotective action of the drug…Yerba Mate (Ilex paraguaiensis) protects dopaminergic neurons degeneration and improve their maturation in culture
Objective: To evaluate the effect of Mate leaves extracts on the survival and maturation of dopaminergic neurons in vitro. Background: Parkinson's disease (PD) is caused…Neuromodulatory role of subthalamic nucleus deep brain stimulation in Parkinson’s disease patients
Objective: The aim of study was to evaluate the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on the motor disabilities and cognitive alterations in…Oral treatment with sphingosine-1-phosphate receptors modulator prevents Parkinson symptoms concomitantly to reduced brain inflammation in MPTP mouse models
Objective: Here we explore the efficacy of an oral treatment with Fingolimod (FTY720), a selective sphingosine-1-phosphate receptors modulator, to prevent MPTP induced nigrostriatal loss and…Study of neuroprotective effects of Ginsenside Rg3 , the prototypal epigenetic Sirtuin-1 activator, in targeting microglia activation and neurotrophic factor (NF) neural plasticity in MPTP model of Parkinson’s disease (PD)
Objective: 1) to examine whether the phyto-neurosteroid: Ginsenoside Rg3 recently demonstrated to activate the epigenetic SIRTI signaling, will rescue the motor impairment in rodent model…Curcumin I prevents the developmental defective sensorimotor patterns resulted from Lead poisoning in rat
Objective: In the present investigation, we evaluated the effect of prenatal exposure of rats to lead from neonatal to adult age on the sensorimotor performances…
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