DAT-SPECT in old onset Parkinson’s disease: should we trust?
Objective: . Background: Scans without evidence of dopaminergic deficit (SWEDD) refers to patients clinically diagnosed with Parkinson’s disease (PD), but show normal findings on dopamine…Progression of nigrostriatal dysfunction in Parkinson’s disease: a longitudinal multimodal PET study
Objective: To investigate the longitudinal course of nigrostriatal metabolic and dopaminergic dysfunction and its impact on symptom severity in Parkinson's disease (PD) patients using a…Eyelid opening apraxia as the first manifestation of Creutzfeldt- Jakob disease with 99mTc-TRODAT-1 brain SPECT study
Objective: Our objective is to report a case of sporadic CJD (CJD) in a 57-years-old male patient. It started with severe insomnia followed by eyelid…Sex-related longitudinal change of motor features and biological biomarkers in early Parkinson’s disease from the PPMI cohort
Objective: We aim to describe sex-related longitudinal changes in (1) motor features and motor aspects of experiences of daily living and (2) biologic measures as…Increased expression of conexin 36 in rodent model of Parkinson disease
Objective: To evaluate changes in non-synaptic mechanisms associated with the procedures to reproduce the neurophysiological conditions typical of Parkinson's disease (PD). Background: Many mechanisms that…Alpha-synuclein preformed fibril (PFF)-triggered synucleinopathy recapitulates neurochemical features of human PD: A PET study in rats
Objective: To investigate longitudinal dopaminergic deficits and similarity to human Parkinson’s disease (PD) using PET imaging in the rat alpha-synuclein (a-syn) preformed fibril (PFF) model.…Genetic Profiling of Early Synucleinopathy in Rat Nigrostriatal Dopamine Neurons
Objective: Identification of changes in gene expression in rat nigral neurons associated with early phases of synucleinopathy. Background: Early phases of synucleinopathies such as Parkinson’s…In vivo imaging of presynaptic terminal loss in early Parkinson’s disease
Objective: To determine the magnitude and anatomical extent of presynaptic terminal damage in early Parkinson’s disease (PD) in vivo, we performed a PET study with…Novel Mutation of NUS1 Gene Presenting With Developmental And Epileptic Encephalopathy and Movement Disorders
Objective: To report the range of movement disorders associated with a NUS1 gene mutation. Background: To date, pathogenic loss-of-function de novoNUS1mutations have been described in only…Striatal dopaminergic regulation of micrographia in parkinsonism
Objective: To investigate the role of brain dopamine function in writing and drawing micrographia of patients with parkinsonism. Background: Micrographia, an abnormally small or progressively…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.