Utility of Digital Olfactory Assessment (Sensify) in Parkinson’s Disease: Preliminary Findings from the IPDGC Africa in Egypt
Objective: Validate a digital olfactory assessment for Parkinson’s disease (PD) in Egyptian participants by comparing olfactory performance in PD patients, healthy controls, and those with…Identifying subjects at high risk for prodromal Parkinson’s Disease using dopamine transporter imaging deficit in a step-wise recruitment strategy: Data of Healthy Brain Ageing (HeBA)
Objective: To optimize screening for subjects with dopamine transporter (DaT) imaging deficit being at high risk for prodromal Parkinson's disease (PD). Background: Efficient screening methods…Alpha-Synuclein Aggregates in the Olfactory Epithelium of Subjects with Parkinson Disease, Dementia, COVID-19, and in Aged Controls
Objective: We sought to examine whether neuroepithelial structures of the nasal cavity differ between individuals diagnosed with a Lewy body disorder vs those with COVID19…PREDIGT 2.0: A Self-Administered, Two-Step Screening Tool to Identify Individuals with Parkinson’s Disease
Objective: To pilot the 2-step PREDIGT Score model for feasibility and improve it by simplifying both steps. Background: We previously demonstrated that the original PREDIGT…16-years of Evaluations for Prodromal Parkinson Features in an At-Risk Cohort with Gaucher Disease
Objective: To evaluate prodromal features of Parkinson disease in a cohort of "at-risk" Gaucher patients and GBA1 carriers . Background: Variants in GBA1 mutations are…Olfactory-Trigeminal Interactions in Parkinson’s Disease Compared to Other Olfactory Disorders
Objective: To investigate the interaction between the olfactory and trigeminal systems in Parkinson’s disease (PD) as opposed to other forms of olfactory dysfunction and controls…Association between Non-Motor Parkinson’s disease symptoms and hyposmia in a population-based cohort
Objective: To describe the association between different Parkinson’s disease (PD) related non-motor symptoms (NMS) and hyposmia in a population-based cohort. Background: Olfactory dysfunction is of…Assembling a Cohort of Hyposmic Participants for Therapeutic Studies Aimed at Parkinson’s Disease (PD) Prevention
Objective: The goal of this project was to amass a cohort of individuals with hyposmia to later invite them to participate in clinical trials for…Identifying Subjects with Dopamine Transporter Deficit in a Population-based Recruitment Strategy: Kassel Data of Healthy Brain Ageing
Objective: To identify subjects with dopamine transporter (DaT) deficit being at high risk for prodromal PD. Background: Neurodegeneration and dopaminergic deficit in PD occur before the development…Loganic Acid Alleviates the Bidirectional Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
Objective: The study aimed to delineate the molecular mechanism involved in bidirectional olfactory-brain dysfunction through the NLRP3 inflammasome signaling activation in in-vitro and in-vivo model…
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