Integrating Non-Motor Symptoms and Gender Variability in Machine Learning for Early Parkinson’s Disease Detection
Objective: Our study aimed to develop a machine learning (ML) model for the early detection of Parkinson's disease (PD), utilizing non-motor symptoms (NMS) and DNA…Odor-specific symptoms in Parkinson’s disease – UPSIT odor identification status versus clinical severity.
Objective: To explore correlations between the identification status of individual odors in the Pennsylvania Smell Identification Test (UPSIT) and the clinical severity of Parkinson’s disease…Parkinson’s disease biomarkers in human olfactory cleft mucus
Objective: To investigate and identify biomarkers for PD from human olfactory cleft mucus Background: Olfactory loss is an early symptom of PD, often preceding motor…Association between Non-Motor Parkinson’s disease symptoms and hyposmia in a population-based cohort
Objective: To describe the association between different Parkinson’s disease (PD) related non-motor symptoms (NMS) and hyposmia in a population-based cohort. Background: Olfactory dysfunction is of…Assembling a Cohort of Hyposmic Participants for Therapeutic Studies Aimed at Parkinson’s Disease (PD) Prevention
Objective: The goal of this project was to amass a cohort of individuals with hyposmia to later invite them to participate in clinical trials for…Identifying Subjects with Dopamine Transporter Deficit in a Population-based Recruitment Strategy: Kassel Data of Healthy Brain Ageing
Objective: To identify subjects with dopamine transporter (DaT) deficit being at high risk for prodromal PD. Background: Neurodegeneration and dopaminergic deficit in PD occur before the development…Loganic Acid Alleviates the Bidirectional Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
Objective: The study aimed to delineate the molecular mechanism involved in bidirectional olfactory-brain dysfunction through the NLRP3 inflammasome signaling activation in in-vitro and in-vivo model…First in vivo evidence of the role of the noradrenergic system in olfactory dysfunction in Parkinson’s disease
Objective: To investigate the relationship between in vivo noradrenergic markers and olfactory impairment in patients with Parkinson’s disease (PD). Background: Degeneration of the noradrenergic (NA)…Understanding the earliest phases of Parkinson’s disease (PD) – an expanding opportunity to study ‘at-risk’/early/prodromal PD in the Global Parkinson’s Genetics Program (GP2)
Objective: To identify and recruit at-risk/early/prodromal Parkinson’s disease (PD) cohorts around the world to the Global Parkinson’s Genetics Program (GP2, http://gp2.org/) and build a global…Bidirectional Relationship Between Olfaction and Parkinson’s Disease
Objective: To establish a causal direction and genetic relationship between olfactory function and Parkinson’s disease (PD). Background: Degradation in olfactory function or hyposmia is a…
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