Unveiling a rare case: Novel TBK1 variant presenting as Multiple system atrophy-like phenotype
Objective: Tumour necrosis factor NF-ƘB activator (TANK) binding kinase 1 (TBK1) is necessary for immune and inflammatory responses. Reports of TBK1 with neurodegeneration are noted…Impaired glymphatic clearance independently contributes to poor outcomes in Parkinson’s disease
Objective: Clarify how glymphatic clearance impacts cognition in PD and its interaction with established imaging markers. Background: Impaired glymphatic clearance may contribute to pathological accumulations…Prevalence and Clinical Characteristics of Parkinson’s disease in Rural Nepal: A Community-Based Cross-Sectional Study
Objective: This study aims to determine the prevalence of PD in rural Nepal and characterize its clinical features in an effort to bridge the gap…Patients’ Perspective on Screening for Non-Motor Symptoms in Parkinson’s Disease, A QI Project
Objective: To assess deficiencies in patient care for individuals with Parkinson's disease in neurology clinics, with a particular focus on nonmotor symptoms. Background: While motor…Beyond Motor Symptoms: The Interplay Between Non-Motor Symptoms and Caregiver Challenges in Late-Stage Parkinson’s Disease
Objective: To assess the relationship of non-motor (neuropsychiatric (NPS)) symptoms with the severity of motor symptoms of Parkinson’s Disease (PD). And to study the impact…Parkinsonism due to Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) Responsive to Carbidopa/Levodopa
Objective: To describe a case of Parkinsonism due to ALSP which is responsive to carbidopa/levodopa Background: Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP)…Misdiagnosis of Cognitive Impairment in Parkinson’s disease
Objective: We explored potential bias to diagnose cognitive impairment in People with Parkinson’s (PwP) followed in the Parkinson’s Progressive Markers Initiative (PPMI). Background: In primary…Genome-wide Survival Analysis Identified Association Between HS1BP3 and APOE loci and Dementia in Parkinson’s disease
Objective: We aim to conduct a genome-wide survival study (GWSS) to identify single nucleotide polymorphisms (SNP) associated with dementia in Parkinson’s disease (PD) with a…How does a diagnosis of Dementia with Parkinson’s influence future care provision?
Objective: To describe the trajectory of Parkinson’s after the onset of dementia including setting of care, frailty levels and mortality rate. Background: Cardiff and Vale…A phase 2 randomized, double-blind, placebo-controlled trial of Ambroxol as a disease-modifying treatment for Parkinson’s disease dementia.
Objective: To evaluate the safety and tolerability of repurposing Ambroxol as a disease modifying treatment for Parkinson’s Disease Dementia (PDD). Background: Carrying a mutation in…
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