Motor Network Neurophysiological (TMS-EEG) Markers as Predictors of Long-Term Outcomes Following Ventriculoperitoneal Shunt in Normal Pressure Hydrocephalus
Objective: Assess the ability of Delphi-MD (TMS-evoked potential (TEP)-based test) to predict long-term (over one year) response to VPS as an ancillary tool to improve decision-making. Background:…Sleep dysfunction and its clinical and video-polysomnographic correlates in patients with early Parkinson’s disease in comparison with early Progressive supranuclear palsy
Objective: To estimate the prevalence and characterise the extend of sleep dysfunction in early Progressive Supranuclear Palsy and in early Parkinson’s disease among the Indian…Parkinsonism Induced By An Interpeduncular Cistern Epidermoid Cyst A Case Report And Literature Review
Objective: To describe a patient with parkinsonism secondary to an interpeduncular cistern cyst causing midbrain compression, highlighting clinical features, structural and molecular imaging findings, and…Repurposing Rifabutin for Neuro-Metabolic Disorders: AMPK-PGC-1α-Driven Mitochondrial Protection in Diabetes Associated Parkinsonism
Objective: To assess the role of rifabutin in restoring mitochondrial function and energy balance through modulation of the AMPK–PGC-1α signaling pathway in diabetes-related Parkinsonism. Background:…Intra-familial phenotypic variability in a novel Autosomal dominant GCH1 variant
Objective: To report a family with a novel variant of the GCH1 gene presenting as early-onset DOPA-responsive dystonia (DRD) and late-onset Parkinson’s disease. Background: Autosomal…Video-Nystagmographic Biomarkers of Oculomotor Dysfunction in Parkinson’s Disease: Correlation With Motor Severity and Cognition
Objective: To quantitatively evaluate oculomotor dysfunction using video-nystagmography (VNG) in patients with Parkinson’s disease (PD) and determine its association with motor severity, disease duration, and…Dystonia parkinsonism revealing CV2 positive autoimmune encephalitis
Objective: To report a case of CV2-positive autoimmune encephalitis presenting as dystonia–parkinsonism, underscoring the need to consider autoimmune etiologies in atypical dystonic syndromes. Background: Autoimmune…Gelsolin and Secretogranin-3 induce Parkinsonian features in rodent models.
Objective: To study the pathogenic potential of Gelsolin (GSN) and Secretogranin-3 (SCG3) in inducing Parkinsonian features. Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder…Clinical Significance of Automatically Assessed Perivascular Space Count in Subcortical White Matter of Parkinson’s Disease
Objective: This study aimed to examine the relationship between automatically quantified perivascular space (PVS) count located in the subcortical white matter (WM), baseline motor deficits,…Degradation Mechanisms of PolyG
Objective: To characterize the polyglycine (polyG) interaction network and identify its degradation mechanisms. Background: polyG translated from GGC repeat expansions in the 5′UTR of NOTCH2NLC…
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