Baclofen-Induced Worsening of Parkinsonism in a Patient with CADASIL and Brainstem Stroke
Objective: To report baclofen-associated worsening of parkinsonism in a patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and recent brainstem infarction,…Magnitude of Non-Motor Symptoms Among People with Parkinson’s Disease in Rural and Urban Tanzania
Objective: We aimed to determine the prevalence of non-motor symptoms in people with Parkinson’s disease. Background: Parkinson’s disease is the second most common neurodegenerative disease…Discontinuation of Parkinson’s Disease Clinical Studies: A Cross-Sectional Analysis
Objective: This study evaluates the characteristics of clinical studies in Parkinson’s disease to identify factors associated with early discontinuation. Background: Clinical studies in Parkinson’s disease are…Efficacy of Combining Outpatient Palliative Care with Standard Care on Quality of Life and Caregiver Burden in Atypical Parkinsonian Syndrome – A Randomised Controlled Trial
Objective: This study evaluates the effectiveness of structured outpatient palliative care combined with standard care compared to standard care alone at 3 and 6 months…The “Guarda” (Tower) Drawing Test: A Novel Bedside Tool to Quantify Bradykinesia in Parkinson’s Disease
Objective: Quantify Bradykinesia Through Standardized Drawing in PD patients. Background: Bradykinesia is the cardinal symptom in Parkinson's Disease (PD). The slowing and progressive reduction in…Standardized Autonomic and Movement Assessment in Mexican Patients with Undetermined and Degenerative Progressive Parkinsonism: A Single-Center Experience
Objective: We proposed a unified and standard autonomic and movement evaluation to discriminate patients' Parkinsonism related to synucleinopathies from other conditions during a clinical office…Beyond the Spinal Tap: Diagnostic Accuracy of Alpha-Synuclein Seeding Amplification Assays (SAA) in Cutaneous and Ocular Biofluids – A Comparative Diagnostic Accuracy Review
Objective: To evaluate the diagnostic performance of alpha-synuclein (a-syn) seeding amplification assays (SAA) in skin and tear fluid (TF) as non-invasive alternatives to cerebrospinal fluid…Traumatic Brain Injury Exacerbates Parkinsonian Neurodegeneration Through Alpha Synuclein Dysregulation
Objective: This study aimed to determine whether repetitive mild traumatic brain injury exacerbates Parkinsonian neurodegeneration and promotes alpha synuclein pathology in an experimental model. Background:…Do Digital Mobility Outcomes Differ Across Clinically Defined NSD-ISS Stages in Parkinson’s Disease?
Objective: To determine whether digital mobility outcomes (DMOs) differ between individuals with relatively advanced PD grouped according to the clinical criteria of the Neuronal α-Synuclein…Real-World Clinical Outcomes of Adaptive versus Continuous Deep Brain Stimulation in Early-Stage Parkinson’s Disease: A Systematic Review and Meta-Analysis of 2024-2025 Trials
Objective: To evaluate the comparative efficacy, safety, and energy efficiency of adaptive deep brain stimulation (aDBS) versus continuous deep brain stimulation (cDBS) in Parkinson’s disease…
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