Relationships of gender, care models, and neuropsychiatric symptoms in Parkinson’s disease
Objective: To examine relationships among gender, care models, and presence and management of neuropsychiatric symptoms of Parkinson’s disease (PD). Background: Neuropsychiatric symptoms such as depression…Evaluating Volume Changes in the Substantia Nigra Pars Compacta (SNc) in Parkinson’s Disease (PD) in a Study-Specific Magnetic Resonance Imaging (MRI) Template
Objective: To characterize the topography of SNc involvement in PD patients using neuromelanin (NM)-sensitive MRI (NM-MRI). Background: PD is characterized by the progressive loss of…“Brain-first” vs. “body-first” Parkinson’s disease is determined by RBD-status – a multi-modality imaging study
Objective: In a multi-modality imaging study, we test the hypothesis that Parkinson’s disease (PD) can be divided into two strikingly distinct phenotypes: (1) PD patients,…Functional Biomarkers of Parkinson’s Disease: Changes in Brain-Wide Network Connectivity in Default Mode and Fronto-Parietal Control Networks
Objective: Parkinson’s disease (PD) is a neurological disorder with no reliable biomarkers. We aimed to investigate naturalistic paradigms as functional biomarkers that distinguish between PD…Genotype influences circuit compensation in Parkinson’s disease
Objective: This study investigates differences in brain network organization in patients with Parkinson’s disease (PD) with genetic risk factors relative to sporadic PD patients and…The efficiency of group cognitive rehabilitation to patients with Parkinson’s disease in comparison to relaxation therapy: pilot data
Objective: The aim of this study was to compare the efficiency of group cognitive rehabilitation to patients with Parkinson´s disease (PD) in comparison to group…Validation of the ‘ecological momentary assessment’ (EMA) method as a tool for daily life monitoring in patients with Parkinson’s disease
Objective: To validate the ‘ecological momentary assessment’ (EMA) method, also known as the ‘experience sampling method’ (ESM), as an instrument to monitor symptoms of PD.…Safinamide improves motor symptoms severity and daily living in Parkinson’s Disease (PD) patients
Objective: To evaluate the clinical effects of safinamide, administered as add-on therapy to levodopa in fluctuating PD patients, on symptoms severity and daily living. Background:…Design, characterization and In vivo evaluation of intranasal delivery of levodopa loaded microspere for Parkinsonism
Objective: Levodopa is the drug of choice in the treatment of Parkinson's disease but it exhibits low oral bioavailability and very low brain uptake. The…Multi-kinase Abelson (c-Abl) and Discoidin Domain Receptors (DDR1/2) inhibitors, Nilotinib, alters CSF soluble TREM2 (sTREM2) in individuals with Parkinson’s Disease
Objective: Our objective was to examine the effects of broad-based tyrosine kinase inhibition in cerebrospinal fluid biomarkers. Background: Nilotinib is a broad-based tyrosine kinase inhibitor…
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