Structural connectivity changes in G2019S-LRRK2 gene mutation carriers without manifest Parkinson’s disease
Objective: We hypothesised that abnormal sprouting of serotonergic terminals in the hypothalamus may lead to abnormal structural connectivity, which can be measured with diffusion tensor…Evaluation of Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s Disease: An in vivo [11C]BU99008 PET study
Objective: We aimed to evaluate the role of astroglia activation in Parkinson's disease (PD) using [11C]BU99008 PET, a novel radioligand with high specificity and selectivity…Mindfulness Based Stress Reduction in People with Parkinson’s Disease and their Carepartners
Objective: To assess the feasibility and impact of mindfulness based stress reduction (MBSR) on people with Parkinson’s disease (PD) and their carepartners. Background: Non-motor symptoms…Prevalence and associated risk factors of early morning off among the patients with Parkinson’s disease in China
Objective: To explore the prevalence and associated risk factors of early morning off (EMO) among outpatients with Parkinson’s disease (PD) in China. Background: PD is…Utilization of Monotherapy and Combination Therapies in Advanced Parkinson Disease Patients During Levodopa-Carbidopa Intestinal Gel Treatment from the COSMOS Study
Objective: Assess the percentages of advanced Parkinson’s disease (APD) patients treated with levodopa-carbidopa intestinal gel (LCIG) as a monotherapy or with add-on PD medications and…Quantitative study of subthalamic ERG potassium channels in parkinsonian discharges
Objective: This study describes the role of the subthalamic ERG Potassium (ERG K+) ion channel conductance in cellular excitability in subthalamic nucleus (STN) neurons towards…Does Gait in Real Life differ between People with Parkinson’s Disease and Healthy Controls?
Objective: We investigated whether: 1) gait in daily life differs in people with Parkinson’s disease (PD) compared to healthy controls (HC), and 2) the length…Differential enhancement of ERK, PKA and Ca2+ signaling in direct and indirect striatal neurons of Parkinsonian mice
Objective: To identify cell-specific and dynamical modifications of signaling pathways associated with PD and drug-induced modifications Background: Parkinson's disease (PD) is characterized by severe locomotor…SNCA G51D missense mutation causing juvenile onset Parkinson’s disease
Objective: To report the clinical and genetic features in a Parkinson’s patient with the SNCA G51D missense mutation. Background: α-synuclein (SNCA) gene mutations are recognized…Development of a web-based tool for systematic collection of phenotypes of hereditary movement disorders from medical literature
Objective: To develop a web-based tool to collect phenotypes of heterditary movement disorders. Background: Deep phenotyping, the precise and comprehensive analysis of phenotypic abnormalities, is…
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