PTRHD1 loss-of-function mutation in an African family with parkinsonism and intellectual disability
Objective: To investigate the clinical features and identify the disease-causing gene in a black South African family affected by juvenile-onset parkinsonism and intellectual disability. Background:…STN DBS modulates cortical auditory processing in advanced Parkinson’s Disease; a MEG-study
Objective: To find out how deep brain stimulation (DBS) impacts cortical auditory processing in advanced Parkinson's disease (PD) patients. Background: Motor symptoms of PD can…The use of DaT scan for diagnosis of Idiopathic Parkinson’s disease and Parkinson’s Plus syndromes in clinical practice (HEFT experience)
Objective: To assess the clear indication for which DaT scan was requested, its specificity and sensitivity and factors that might be considered for future clinical…Brain network activation (BNA): A new biomarker for Parkinson’s disease?
Objective: We aimed to assess the ability of the Brain Network Activation (BNA) EEG analysis algorithm to differentiate between early-stage Parkinson’s disease (PD) patients and…Gender Differences in Parkinson’s disease: Transcranial Magnetics Stimulation Study of Newly Diagnosed Drug-Naïve PD Patients
Objective: In early Parkinson’s disease (PD), functional changes may be detected in primary motor cortex (M1) using transcranial magnetic stimulation (TMS). We hypothesised that, if…Clinical subtypes of Parkinson’s disease based on nonmotor symptoms: A cluster analysis
Objective: To classify patients with early Parkinson's disease based on nonmotor symptoms using a data-driven approach. Background: Heterogeneity of Parkinson’s disease provides the basis for…The Clinical Research of Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
Objective: To compare the differences of clinical characteristics between PD patients with rapid eye movement sleep behavior disorder (RBD) (RBD+ group) and those without RBD…Impact of injection guidance techniques on the efficacy and safety of incobotulinumtoxinA for sialorrhea
Objective: SIAXI (NCT02091739), a pivotal double-blind, randomised, placebo-controlled study with an extension period (EP), assessed the efficacy and safety of incobotulinumtoxinA 75 or 100 U…Effects of neural stem cell transplantation on the differentiation of dopaminergic neurons in the substantia nigra and changes to rotational behavior of Parkinson’s disease rats
Objective: To explore the effects of neural stem cells transplantation on the differentiation of substantia nigra dopaminergic neurons and on the rotational behavior in a…Decreased amyloid-beta in patients with Idiopathic Parkinson’s Disease and white matter hyperintensities
Objective: The aim of this study is to investigate the clinical and biochemical profile of patients with PD with and without WMH. Background: Parkinson’s disease…
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