Tau and α-synuclein autoantibodies as potential biomarkers for Parkinson’s and Alzheimer’s diseases
Objective: To investigate the value of the naturally occurring serum AIAs of α-synuclein (α-syn) and tau, proteins as potential biomarker for diagnosis of PD in…Modulation of CaMKIIa-NR2B interaction in levodopa-induced dyskinesia in 6-OHDA- lesioned Parkinson’s rats
Objective: In the present study, therefore, we examined the relationship between CaMKII and NR2B in levodopa-induced dyskinesia rats. Background: Long-term treatment with L-dopa leads to…Preliminary Results of Psychometric Properties of the Freezing of Gait Questionnaire in Turkish Patients with Parkinson’s Disease
Objective: To investigate the validity and reliability of the Freezing of Gait Questionnaire (FOG-Q) in Turkish Parkinson’s disease (PD) patients. Background: Freezing of gait is…Clinical study on the correlation between Parkinson’s somatosensory evoked potentials and STN-DBS parameters
Objective: Indications for STN-DBS are assessed based on the clinical symptoms. Our test was a clinical study on the correlation between amplitude and latency of…Effects of PGE inhibition on Striatal Neuroinflammation in 6-OHDA lesion
Objective: In this study, we investigated the role of prostaglandin E2 inhibition, pro-inflammatory cytokine concentration and microglial activation in a Parkinsonian rat Background: Neuro-inflammation plays…Carbon Monoxide Poisoning-Induced Parkinsonism: A Prospective Study of Clinical and Neuroimage Correlation
Objective: To investigate prospectively the nigrostriatal system in patients with delayed post-anoxic Parkinsonism by TRODAT-1 brain SPECT serially and to correlate the neuropsychiatric performance and…SYN120 (a Dual 5-HT6/5-HT2A Antagonist) Study to Evaluate Safety, Tolerability and Efficacy in Parkinson’s Disease Dementia (SYNAPSE): Phase 2a Study Results
Objective: To evaluate the safety and preliminary efficacy of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is an antagonist of serotonin receptors…Outcomes of a Prospective, Multi-center International Registry of Deep Brain Stimulation for Parkinson’s Disease
Objective: The objective this report is to describe collected outcomes from a large scale registry of a Deep Brain Stimulation (DBS) system capable of Multiple…Update on The Personalized Parkinson Project: Partnering with Patients to Understand Disease Progression Through a Multi-Dimensional Approach
Objective: Enrollment for The Personalized Parkinson Project (PPP) is underway. Co-design and mutual partnership between patients and researchers is a key characteristic of the project…Contribution of ATP-sensitive potassium channels in the subthalamic nucleus neurons towards Parkinson’s disease
Objective: This study describe a quantitative investigation to explore the modulating effects of the ATP-dependent Potassium channel (KATP) ion channel conductance on spike patterns in…
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