Functional Connectivity Differences Across Parkinson Disease Subtypes
Objective: The goals of this project were to 1) identify putative Parkinson disease (PD) clinical subtypes and 2) investigate resting-state functional connectivity differences between these…Multicenter Validation of Disease- related Parkinson’s disease pattern with Resting State functional MRI
Objective: To validate Parkinson’s Disease-related network topography characterized with resting-state functional MRI (rs-fMRI) in two multicenter based cohorts of idiopathic Parkinson’s disease (IPD) patients. Background:…Olfactory Impairment in Parkinson’s Disease and White Matter Abnormalities in Central Olfactory Areas
Objective: To determine white matter abnormalities in PD patients with various degrees of olfactory impairment. Background: Neuroimaging results of PD brain based on diffusion tensor…Analysis of related factors of occurrence of dementia in Parkinson’s disease using the application form of Parkinson’s disease provided by the specific diseases treatment research program of Ministry of Health, Labor and Welfare of Japan
Objective: Dementia has now been noticed as a significant non-motor symptom of Parkinson's disease (PD). We attempted to analyze the relation between the occurrence of…Is cognitive decline similar among Parkinson’s disease motor sub-types? A prospective study examining changes over time in gait, balance and cognition
Objective: To investigate whether changes over time in cognitive and motor functions differ across the postural instability gait difficulty (PIGD) and tremor dominant (TD) motor…Subjective visual vertical in patients with early Parkinson’s disease
Objective: To identify the changes of subjective visual vertical and any correlation between SVV and cognitive/motoric dysfunctions in Parkinson's disease. Background: Dysfunction of sensory system is…Randomize study of occurrence of Parkinson’s syndrome in patients with rheumatoid arthritis.
Objective: We aimed to study an occurrence of Parkinson’s syndrome (PS), its relationship with duration of disease and age of patients with rheumatoid arthritis. Background:…Parkinsonism through astrocytic GABA induce motor symptoms
Objective: Although reactive gliosis is a prominent feature of PD, its role in pathogenesis has remained elusive. Here we show that aberrantly synthesized GABA from reactive astrocytes tonically inhibits neighboring dopaminergic neuronal firing in SNpc, reducing dopamine production and release, leading to parkinsonian motor symptoms. Background: Parkinsonism is a clinical syndrome of movement abnormalities seen in Parkinson’s disease (PD), which has been attributed to cell-autonomous mechanism of doparminergic neuronal death in the substantia nigra pars compacta (SNpc). Methods: To identify the…The diagnostic challenges of patients with possible multiple system atrophy
Objective: The aim of the this study to review the diagnostic challenges of MSA and to evaluate the patients with different clinic types of MSA-…Neurogenic Orthostatic Hypotension Burden of Illness Patient and Caregiver Survey: Impact of Symptoms
Objective: To determine the impact of neurogenic orthostatic hypotension (nOH) on the quality of life (QoL) of patients with autonomic dysfunction and the burden on…
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