A novel cause for unpredictable response to levodopa
Objective: [To describe a novel cause for unpredictable response to levodopa] Background: A fluctuating response to levodopa is common in advanced Parkinson’s disease and can…Neuroticism and depression is associated with impulse control disorder in Parkinson’s disease: a controlled study
Objective: Cross-sectional assessment of personality trait, impulsivity, depression and anxiety collected prospectively in Parkinson’s disease (PD) with impulse control disorders (PD-ICD) compared to a matched…Sleep architecture in Parkinson´s disease and Parkinson’s disease associated dementia
Objective: To evaluate the differences in early sleep architecture between patients with Parkinson’s disease (PD) and Parkinson’s disease associated dementia (PDD). Background: Disorders of sleep…Parkinson’s disease in untreated Gaucher patients is associated with reduced glucosylsphingosine (Lyso-Gb1) serum levels
Objective: To assess the role of glycosphingolipids in increased risk of Parkinson's disease (PD) in patients with Gaucher disease (GD). Background: Patients with GD are…The identification of molecular-genetic background of familial atypical parkinsonism in “Hornacko”, a specific region of the south-eastern Moravia, Czech Republic.
Objective: To assess the genetic background in the pedigrees with identified autosomal-dominant inheritance of parkinsonism. Background: Increased prevalence of parkinsonism with cognitive deterioration was detected…Capgras syndrome in advanced Parkinson disease
Objective: The aims of this study were to investigate the frequency of Capgras syndrome in Parkinson's disease patients who have undergone Deep Brain Stimulation (DBS)…Serum uric acid levels and freezing of gait in Parkinson’s disease
Objective: To investigate the relationship between serum Uric acid (UA) levels and freezing of gait (FOG) in Parkinson’s disease (PD). Background: UA is a natural…Differential Item Functioning in the Unified Dyskinesia Rating Scale (UDysRS)
Objective: Test if differential item functioning (DIF) due to gender, age, race/ethnicity or education level is present in UDysRS items. Background: Testing a rating…Self Perception of Dysphagia in Parkinson Disease
Objective: To determine when individuals with Parkinson disease (PD) perceive impairment of swallowing as it relates to time since diagnosis. Background: Dysphagia, and particularly silent…Study Design of an Efficacy and Safety Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial of APL-130277 in the Treatment of OFF Episodes (CTH-300)
Objective: To review the unique features of the ongoing Phase 3 trial for APL-130277. Background: Patients with Parkinson’s disease (PD) frequently develop problematic OFF episodes…
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