Genetic, epigenetic and expression profiles in alpha-synucleinopathies
Objective: To determine whether each of the alpha-synucleinopathies has distinct methylation and/or expression profiles that distinguishes them from other disorders in this class. Background: The…Baseline Clinical Predictors of Future Psychotic Symptoms in de novo Parkinson Disease
Objective: To determine which baseline clinical symptoms are associated with future psychotic symptoms in de novo Parkinson disease (PD). Background: Because psychosis in PD is…How do Parkinson’s Disease patients manage Ramadan Fasting?
Objective: To describe how Parkinson's disease(PD) patients manage Ramadan fasting and the impact of the fasting period on symptoms Background: Although Ramadan fasting is not…Rehabilitation program with or without a whey protein-based nutritional support enriched with essential aminoacids and vitamin D in patients with Parkinson’s disease or parkinsonism: study design of a randomized, controlled trial.
Objective: Objective. To evaluate whether the use of a whey protein-based nutritional formula enriched with essential aminoacids – particularly leucine - and vitamin D have…Self Perception of Dysphagia in Parkinson Disease
Objective: To determine when individuals with Parkinson disease (PD) perceive impairment of swallowing as it relates to time since diagnosis. Background: Dysphagia, and particularly silent…Study Design of an Efficacy and Safety Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial of APL-130277 in the Treatment of OFF Episodes (CTH-300)
Objective: To review the unique features of the ongoing Phase 3 trial for APL-130277. Background: Patients with Parkinson’s disease (PD) frequently develop problematic OFF episodes…Effect Of Non-Invasive Vagus Nerve Stimulation In Freezing And Oxidative Stress In Parkinson’s Disease Patients
Objective: In this observational pilot study we explored the long term effect of Non-Invasive VNS to improve the FOG and reduce oxidative stress in PD…Is inter-limb coupling modified by subthalamic deep brain stimulation and dopaminergic medication in Parkinson’s disease?
Objective: We characterized different aspects of bimanual coordination in patients with PD, including inter-limb coupling, and then determined whether they were altered by therapeutic modulation…Deep brain stimulation in the STN of a Parkinsonian rat model overexpressing human A53T α-synuclein in the substantia nigra – A proof of principle
Objective: To determine if subthalamic nucleus (STN)-deep brain stimulation (DBS) leads to a measurable functional improvement of motor deficits in an AAV1/2 A53T α-synuclein (aSyn)…Is awake intraoperative mapping still necessary for bilateral subthalamic stimulation for Parkinson’s disease in a modern surgical environment?
Objective: To study the impact of the absence of awake clinical evaluation during subthalamic nucleus (STN) deep brain stimulation (DBS) on parameters of stimulation and…
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