Regional differences in the results of a phase 2b study of tozadenant in Parkinson’s disease patients with motor fluctuations
Objective: To assess how the efficacy of tozadenant differed by region in a randomized, double-blind, placebo-controlled trial of Parkinson's disease patients with motor fluctuations. Background:…Distribution of oscillatory activities in MRI confirmed subthalamic nucleus subregions
Objective: To explore the differences and similarities of oscillatory activity between subregions of the subthalamic nucleus (STN). Background: In Parkinson's disease (PD), treatment driven changes…Stimulation of the globus pallidus internus in the treatment of Parkinson’s disease: Long-term results of a monocentric follow-up
Objective: To investigate the long-term outcome of pallidal deep brain stimulation (GPi-DBS) in Parkinson's disease (PD). Background: GPi-DBS is beneficial in patients with advanced levodopa-responsive…The effect of short pulse width neurostimulation in GPi-DBS
Objective: To evaluate (1) clinical usefulness and (2) adverse effects of thirty microseconds pulse width stimulation in deep brain stimulation of the globus pallidus internus…Variability in the ideal target of GPi DBS for Parkinson’s disease requires advanced direct targeting for optimal results
Objective: Our findings have the potential to transform the clinical practice of surgeons who rely solely on indirect targeting, by raising awareness of the anatomic…Could tonic chin electromyogram density be a potential marker for differentiating atypical Parkinsonian syndromes from Parkinson’s disease among alpha-synucleinopathies?
Objective: The study aimed to examine whether the video-polysomnography (vPSG) could provide some clues for differentiating atypical Parkinsonian syndromes (APS) from Parkinson's disease (PD) among…Impulse control disorder associates with tyrosine hydroxylase 2 gene variants in Parkinson’s disease patients subject to dopaminergic therapy
Objective: The aim of this study was to identify novel genetic variants associated with Impulse control disorder (ICD) manifestation in PD patients subject to dopaminergic…A cross-sectional study of sensor-based gait analysis in atypical Parkinsonian disorders
Objective: Primary objective was to identify quantitative markers of gait impairment in patients with idiopathic Parkinson's disease (IPD), atypical Parkinsonian disorders (APD) and healthy controls…Loss of FBXO7 (PARK15) leads to disturbances in proteasomal function and models parkinsonism-like and pyramidal symptoms in mice
Objective: To model Parkinsonian-pyramidal syndrome (PARK15) in mice and investigate the impact of loss of F-box only protein 7 (FBXO7) in neurons on proteasomal activity.…Greater incidence of depressive symptoms in atypical parkinsonism: Importance of early screening
Objective: To evaluate the incidence of depressive symptoms in Parkinsonian patients in a large cohort followed at a tertiary movement disorders center. Background: Despite relative…
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