An exuberant cortical γb influences the unmasking and intensity of dyskinesia in 6-OHDA-treated freely-moving rats
Objective: To clarify the pathogenetic role of Beta band (βb) and Gamma band (γb) in 6-OHDA-treated freely-moving rats, by combining histochemical and electrophysiological investigations. Background:…APL-130277 is a sublingual film being studied in phase 3 trials to rapidly turn patients ON from OFF episodes by delivering apomorphine via the oral mucosa
Objective: Evaluate if any differences exist in the efficacy of APL-130277 doses to turn a patient with Parkinson's disease (PD) from OFF to fully ON…Intrastriatal injection of ionomycin profoundly changes motor response to L-DOPA and its underlying molecular mechanisms
Objective: We investigated whether intrastriatal injection of ionomycin to hemiParkinsonian rats produced changes in L-DOPA responses including LID and analyzed the effects of ionomycin on…To new method of tremor assessment
Objective: To develop a new approach to quantitative assessment of Parkinson's tremor based on the calculation of the area of recorded wave of tremor at…May substantia nigra volume asymmetry be an indicator of motor asymmetry in Parkinson’s disease? A retrospective analysis
Objective: We investigated whether smaller substantia nigra is associated with worse parkinsonism on the corresponding contralateral side. Background: Degeneration of dopaminergic cells and morphologic changes…Predicting incident impulse control disorder behaviour in Parkinson’s disease patients using a clinical-genetic model
Objective: Our aims were to estimate ICD heritability and to predict incident ICD behaviour by a candidate genetic multivariable panel in PD patients. Background: Impulse…Botulinum toxin treatment of freezing of gait in Parkinson’s disease patients as reflected in functional magnetic resonance imaging of leg movement
Objective: To reflect botulinum toxin treatment of freezing of gait in Parkinson´s disease patients in functional magnetic resonance imaging of leg movement. Background: Freezing of…Cerebellar GABA-A receptor activity is inversely correlated with gait speed in Parkinson’s disease
Objective: To investigate the relationship between regional cerebral expression of benzodiazepine receptors and gait speed in Parkinson's disease (PD). Background: Flumazenil is a short-acting intravenously…DTI in Parkinson’s disease: Asymmetric progression
Objective: To study the rate of change of brain region diffusion tensor imaging (DTI) parameters between the right and left sides in PD patients using…Impact of datscan on clinical decision making: diagnosis and management of clinically uncertain Parkinsonian syndromes
Objective: To assess changes in clinical diagnosis and/or treatment of 200 consecutive patients with clinically uncertain Parkinsonian syndromes who underwent DaTscan imaging with ioflupane for…
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