Trajectories of prediagnostic functioning in Parkinson’s disease during 14 years before clinical onset
Objective: We studied trajectories of daily functioning and motor and nonmotor features during 14 years preceding clinical Parkinson's disease (PD) onset. Background: In the ten…A study to assess the quality of life and strain in caregivers of people with Parkinson’s disease in India
Objective: This paper investigates the quality of life and strain of caregivers of people with Parkinson's disease. Background: Support of caregivers often enables the patients…Assessment of the quality of life of patients with Parkinson’s disease
Objective: Purpose of investigation was to study the effect of motor disorders to quality of life of patients with Parkinson's disease. Background: In recent years,…Caring for the majority: Telemedicine management of Parkinson’s disease (PD) in underserved populations in People’s Republic of China: A randomized trial
Objective: To improve PD care using expert telemedicine consultation to assist community neurologists in managing PD. Background: Half of the world's PD patients live in…Exome sequencing in dementia with Lewy bodies
Objective: To perform a comprehensive analysis of genes previously implicated in dementia with Lewy bodies (DLB) by exome sequencing of a pathologically confirmed DLB cohort.…Genetic analysis of CHCHD2 gene in Parkinson’s disease in a Taiwanese population
Objective: To evaluate the genetic mutations of CHCHD2 gene in Taiwanese Parkinson's disease patients. Background: A recent study identified a missense mutation in coiled-coil-helix-coiled-coil-helix domain–containing…Risk prediction modeling in Parkinson’s disease using genetic and environmental/lifestyle factors
Objective: To assess the potential of Parkinson's disease (PD) risk prediction using a comprehensive list of genetic and environmental/lifestyle factors associated with PD. Background: Parkinson's…Defective ubiquitinated mitochondria accumulation in aged Parkinsonian LRRK2R1441G knockin mice
Objective: (1) To determine potential accumulation of defective ubiquitinated mitochondria in the brains of aged LRRK2R1441G knockin (KI) mice and their age-matched wildtype controls; and…Selenotranscriptomic analyses identify signature selenoproteins in brain regions in a mouse model of Parkinson’s disease
Objective: In this study, we investigated the selenotranscriptome (24 selenoproteins in total) in five brain regions (cerebellum, substantia nigra, cortex, pons and hippocampus) in a…Chronic cerebral hypoperfusion accelerates cognitive dysfunction and microvascular impairment in the MPTP mouse model of Parkinson’s disease
Objective: To evaluate cerebral hypoperfusion on cognitive dysfunction and related microvascular impairment in the MPTP mouse model. Background: Vascular pathology and Parkinson's disease (PD) pathology…
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