Can clinical outputs predict BDNF levels in people with Parkinson’s disease?
Objective: To modelling the relationship between Brain-Derived Neurotrophic Factor (BDNF) levels and clinical variables (stages of disease and cognition) in people with Parkinson's disease (PD).…Parkinson’s Disease Clinical Subtypes: Symptom Progression, Dementia, and Mortality
Objective: Identify Parkinson's disease (PD) clinical subtypes using multi-domain classification; determine subtype symptom progression; assess subtype clinical utility. Background: People with PD present with combinations…An introduction to the Global Parkinson’s Genetics Program (GP2)
Objective: Expanding the current understanding of the genetic architecture of Parkinson’s disease (PD), accelerate discovery and validation of novel disease-causing genetic mutations and provide training…Whole-exome sequencing in early-onset Parkinson’s disease among ethnic Chinese
Objective: The objectives of this study were to assess the genetic and clinical features of early-onset Parkinson’s disease (EOPD) among ethnic Chinese from mainland China.…mRNA level and variants of the SCARB2 gene in the pathogenesis of Parkinson’s disease
Objective: The aim was to test an association of rs6812193 and rs8475 of the SCARB2 gene with Parkinson’s disease (PD) in case–control study in Russia.…Sex-related longitudinal change of motor features and biological biomarkers in early Parkinson’s disease from the PPMI cohort
Objective: We aim to describe sex-related longitudinal changes in (1) motor features and motor aspects of experiences of daily living and (2) biologic measures as…Investigating Substantia Nigra Damage using Fully Automated Segmentation of Neuromelanin MRI in Early Parkinson’s Disease
Objective: Development of reliable imaging biomarkers of dopaminergic cell neurodegeneration is crucial to facilitate therapeutic drug trials in Parkinson's disease (PD). Neuromelanin-sensitive (NM) MRI techniques…Thalamic nuclei volumes and intrinsic thalamic network in motor subtype in Parkinson’s disease
Objective: The aim of this study is to investigate the alterations of thalamic nuclei volumes and intrinsic thalamic network in patients with de-novo PD according…Impairment of the mesocortical dopamine system in Parkinson’s disease patients with freezing of gait in a multimodal imaging approach
Objective: To investigate the involvement of dopaminergic systems in Parkinson’s disease (PD) patients with freezing of gait (FOG) using a multimodal assessment involving 18 F-DOPA-PET…Bilateral double beta peaks in a PD patient with STN electrodes
Objective: We aimed to record LFPs of the subthalamic nucleus (STN) from a PD patient with a new implantable pulse generator (IPG), which is capable…
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