Characterizing Global Cohorts with Monogenic Parkinson’s Disease
Objective: To clinically and genetically characterize a global sample of subjects with monogenic Parkinson’s disease (mPD) and unaffected mutation carriers. Background: Publications on patients with…Compartment-specific blockade of dopamine uptake in nigrostriatal pathway reveals role for nigral dopamine function in movement frequency in open-field
Objective: Inhibition of tyrosine hydroxylase activity in the substantia nigra (SN) produces a significant reduction in locomotor motor activity commensurate with decreased dopamine (DA) content…Nucleus basalis of Meynert free-water distinguishes and predicts cognitive impairment and longitudinally correlates with cognitive changes in early Parkinson’s disease
Objective: To explore diffusion-based MRI assessments of the nucleus basalis of Meynert (nbM) as a neuroimaging biomarker of cognitive abilities and longitudinal cognitive changes in…Intrinsic Remodeling of the Fovea is Correlated with Contrast Sensitivity Loss in Parkinson’s Disease
Objective: The aim of the study was to determine a technical parameter of foveal pathology that is best suited for discriminating Parkinson’s disease (PD) eyes…Progression of cortical thinning in Parkinson’s disease
Objective: We sought to validate cortical thickness as an objective biomarker of Parkinson’s disease (PD) progression. Background: Cortical thickness analysis has been proposed as a…The Many Faces of Bradykinesia in Parkinson’s Disease : The Quantitative Analysis from A Keyboard Typing Test
Objective: To explore the characteristics of bradykinesia in PD via a keyboard typing test. Background: Bradykinesia is one of the cardinal symptoms in Parkinson’s disease…Is probable REM sleep behavior disorder a risk factor of impulsive-compulsive behaviors in Parkinson’s disease? PPMI study
Objective: To assess the association of REM sleep behavior disorder (RBD) with the development of impulse compulsive behaviors (ICBs) in patients with early Parkinson’s disease (PD)…How cultural beliefs buffer against suicide in Parkinson’s disease patients with Depression: An Indian Karmic Perspective
Objective: To explore the protective factors associated with suicide from an Indian perspective. Background: The Sanskrit word karma is derived from “Kri” which means “to…Gender-related differences in nonmotor symptoms in the context of subthalamic stimulation in Parkinson’s disease
Objective: To investigate gender differences in quality of life, motor, and nonmotor symptoms (NMS) in patients with Parkinson’s disease (PD) undergoing subthalamic nucleus deep brain…Identifying biomarkers to predict disease progression in early stage Parkinson’s disease patients
Objective: To evaluate the sensitivity of instrumented measures of motor dysfunction and candidate serological markers of disease to predict disease progression in de novo Parkinson’s…
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