Deciphering the Role of Auranofin-Loaded Nanoparticles Against Rotenone Model of Parkinson’s Disease: Via GSK-3β/ Nrf2/HO-1 Signaling Pathways
Objective: To investigate the neuroprotective effect of AUF-loaded nanoparticles in animal models of Parkinson's disease by modulating GSK-3β/ Nrf2/HO-1 Signaling Pathways. Background: Parkinson's disease (PD) is…Genetic signatures stratify PwP into three subgroups with differing responses in two disease-modifying Phase 3 trials and indicate multiple disease biology pathways to Parkinson’s Disease
Objective: To evaluate if 3 newfound genetic subgroups represent differing aspects of disease biology in PD by determining if subgroup participants have differing responses to…Safety and Tolerability of Bemdaneprocel in People With Parkinson’s Disease: Results up to 24 Months From a Phase 1 Study
Objective: To report the safety and tolerability of bemdaneprocel in participants with Parkinson’s disease (PD) up to 24 months post transplantation. Background: Bemdaneprocel is an…Resting-State Network Alterations in Patients with Isolated REM Sleep Behavior Disorder and their Association with Clinical Symptoms
Objective: To characterize brain functional connectivity (FC) in patients with isolated REM sleep behavior disorder (iRBD) and its associations with clinical features. Background: Patients with…Decrease in Walking Ability with Increased Functional Connectivity between Multiple Brain Areas in Parkinson’s Disease
Objective: To compare the functional connectivity of PFC, PMC, and PSC regions during walking between individuals with Parkinson's disease and healthy controls. Background: Gait disturbances…Evaluating the association between cognitive impairment and striatal VMAT2 binding using [18F]AV-133 PET in Parkinson’s disease
Objective: To evaluate the association between cognitive deficits and striatal vesicular monoamine transporter type 2 (VMAT2) binding in participants with Parkinson’s disease (PD) using [18F]AV-133…MRI Visible Perivascular Spaces are Associated with Disease Duration and Severity in Parkinson’s Disease
Objective: Determine whether enlarged perivascular spaces (ePVS) in Parkinson's disease (PD) is associated with worsening motor symptoms and disease progression. Background: PVS are fluid-filled channels…Gait Analysis in the 6-Hydroxydopamine Hemiparkinson Rat Model with Deep Brain Stimulation in the Subthalamic nucleus
Objective: The study aims to quantify motor improvement after chronic subthalamic nucleus deep brain stimulation (STN-DBS) in the 6-hydroxydopamine (6-OHDA) hemiparkinson rat model using a…Comparison of two methods of deep brain stimulation lead reconstruction and their prediction capacities
Objective: The study evaluates the prediction capacity of two different Deep brain stimulation (DBS) electrode reconstructions methods: Lead-DBS and StimView . The methods predictions of…Surprising Somatotopy: Buccinator Dyskinesia (Orobuccal Popeye Sign) Induced by Subthalamic Brain Stimulation in Parkinson’s Disease
Objective: To describe a clinical case of buccinator movements evoked by subthalamic nucleus deep brain stimulation (STN-DBS) in a patient with advanced Parkinson's disease (PD)…
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