Unraveling the Variability in Amantadine Response for Levodopa-Induced Dyskinesias: The Impact of Clinical and Genetic Factors
Objective: To identify demographic, clinical, and genetic factors associated with the outcomes of amantadine treatment in dyskinetic Parkinson’s disease (PD) patients. Background: While recent advancements…Treatment Stability Across Different ADD-ON Therapies in Fluctuating Parkinson’s Disease
Objective: This study investigates the efficacy and tolerability of selegiline (SL), rasagiline (RS), safinamide (SF), and opicapone (OP) in fluctuating PD patients, focusing on treatment…Phosphorylated High Mobility Group Box Protein 2 (HMGB2) as a Potential Biomarker for Parkinson’s Disease
Objective: We recently showed that HMGB2 is secreted during ferroptosis and as ferroptosis is involved in the etiology of PD, we have examined the possibility…Alpha-Synuclein Amplification Assays Utilizing Real-Time Quaking-Induced Conversion (RT-QuIC) from Non-Invasive Saliva as a Novel Diagnostic Tool for Patients with Parkinson’s Disease
Objective: The main objective is to evaluate the sensitivity of aSyn-RT-QuIC in diagnosing Parkinson's Disease (PD) from non-invasive saliva. The results will be corroborated in…Dried Plasma Spot Cards for Measurement of Neurofilament Light Chain
Objective: Evaluate measurement of neurofilament light chain (NfL) in dried plasma spot cards, and to compare these to measurements using more invasive and in person…Cognitive and Motor Wobbling in Isolated RBD: A Multicentric Study by the International RBD Study Group (IRBDSG)
Objective: To define and characterize clinically fluctuating transition phases from isolated RBD (iRBD) to overt alpha-synucleinopathy. Background: Patients with iRBD often develop motor and non-motor…Novel Usage of Alpha Synuclein as a Biomarker for Screening Parkinson’s disease at Komfo Anokye Teaching Hospital in Ghana
Objective: This study aimed to assess the use of alpha-synuclein as a biomarker for PD screening and investigate its correlation with disease severity. Background: The…Neural Signatures of Hallucination Emergence in Dementia with Lewy Bodies
Objective: REM sleep behavior disorder (RBD) is a prodromal state for alpha-synucleinopathy. Here, we present a behavioral marker for hallucination propensity that distinguishes Dementia with…Comparative Analysis of MoCA Scores Between Latin American Latinos and White Patients with Parkinson’s Disease
Objective: The study objectives were to 1) characterize scores on the Montreal Cognitive Assessment (MoCA) in patients with Parkinson’s disease (PD) from Latin America, 2)…Modeling Dementia in Patients with Parkinson’s Disease Years After DBS
Objective: The objective of this study is to identify pre-operative cognitive characteristics of patients who are candidates for deep brain stimulation surgery that may contribute…
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