First in Class ASO Targeting A53T Allele: Preclinical Efficacy
Objective: Our objective was to develop an antisense oligonucleotide (ASO) allele-specific strategy to target the mutant A53T SNCA allele, reducing aberrant α-synuclein production, without downregulating…Rapid Neurologic Decline after Subthalamic Nucleus Deep Brain Stimulation in Leucine-Rich Repeat Kinase 2 Parkinson’s disease (LRRK2-PD)
Objective: To describe the clinical outcomes of two unrelated patients with LRRK2-PD who experienced rapid neurologic decline following subthalamic nucleus deep brain stimulation (STN-DBS). Background:…Genetic Analysis of Parkinson’s Disease in Crete
Objective: We aimed to investigate the genetic architecture of Parkinson’s disease (PD) in the island-based Cretan population by identifying pathogenic/likely pathogenic variants (ACMG criteria), in…Insights into Ancestral Diversity in Parkinson’s Disease Risk: A Comparative Assessment of Polygenic Risk Scores
Objective: This study aims to provide a comprehensive assessment of PRS performance across ancestries and highlight the limitations of a “one-size-fits-all” approach to genetic risk…Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations
Objective: The influence of genetics has been primarily studied in European populations, limiting our understanding of the genetic landscape of PD in the African and…Outcome of Subthalamic nucleus deep brain stimulation: comparison between clinical-based and LFP-based programming
Objective: To determine whether outcomes from STN DBS for PD using clinical-based selected active contacts can be improved by revising stimulation contact based on intraoperative…Theta-Burst Subthalamic Deep Brain Stimulation for Parkinson’s Disease: A Pilot Study of Motor and Cognitive Effects
Objective: To evaluate the feasibility and preliminary effects of theta-burst stimulation (TBS) on motor function and verbal fluency in Parkinson’s disease (PD) patients with subthalamic…Stimulation-Entrained Gamma-Driven Adaptive DBS Improves Motor Diary Reports of Symptom Fluctuations in Parkinson’s Disease
Objective: To compare adaptive deep brain stimulation (aDBS) using stimulation-entrained gamma oscillations as a feedback signal to conventional constant-amplitude deep brain stimulation (cDBS) using validated…Living Deep Brain Stimulation for External Control of Striatal Dopamine
Objective: To develop a therapeutic system to allow real time modulation of striatal dopamine release using a living electrode composed of optogenetically controlled dopaminergic neurons.…Clinical characteristics and motor dysfunction in probable REM sleep behavior disorder(pRBD): Insights from CHECK-PD community-based screening project
Objective: To investigate the prevalence of pRBD and examine its characteristics and motor dysfunction through a community-based screening initiative. Background: RBD is a well-recognized predictor…
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