Expanded Parkinson’s Disease GWAS in African Ancestry Populations Identifies Novel Risk Loci and Precision Medicine Targets
Objective: To conduct the largest genome-wide association study (GWAS) of Parkinson's disease (PD) in African (AFR) and African admixed (AAC) ancestry populations to identify ancestry-specific…Reduced Glucocerebrosidase Activity Is Associated with Cognitive Decline in Severe GBA1-Associated Parkinson’s Disease
Objective: To analyse glucocerebrosidase (GCase1) activity in GBA1-PD patient-derived fibroblasts and blood and to compare it with sporadic PD (sPD) and controls at baseline and…Smartphone-Based Multilingual Application for Remote Screening and Monitoring of Motor Symptoms Associated with Parkinson’s Disease
Objective: This project, funded by the Department of Science and Technology, West Bengal, aims to develop a smartphone-based system for remote screening and monitoring of…Effect of Random Training–Test Splits on Radiomic Classification of Parkinson’s Disease from T1-Weighted MRI in Machine Learning
Objective: Assess the effect of random train–test splits on performance in a small T1-weighted MRI radiomics dataset with machine learning. Background: Radiomic MRI analysis is…Nigrostriatal Dopaminergic Patterns in Dementia with Lewy Bodies and Parkinson’s Disease Subtypes: A DAT-SPECT Study within the SOC Framework
Objective: To determine whether the pattern of nigrostriatal dopaminergic degeneration in DLB mirrors that of “body-first” PD using DAT-SPECT imaging. Background: Dementia with Lewy bodies…Clinical Characteristics of Gastric Motility Disorder in Early-Stage Parkinson’s Disease and Its Longitudinal Predictive Value for Disease Progression
Objective: To evaluate the clinical characteristics of gastric motility disorder (GMD) in early-stage Parkinson’s disease (PD) and investigate the predictive value of baseline objective gastric…Insight into α-synuclein pathogenicity by a human cell model with suppressed NatB-mediated N-terminal acetylation
Objective: Our aim was to study α-syn Nt-acetylation and its impact on the disease-relevant properties of this protein in cell models to shed light on…Abdominal Binders to treat Orthostatic Hypotension in Parkinsonian Syndromes
Objective: To investigate the efficacy of an elastic abdominal binder on signs and symptoms of orthostatic hypotension (OH) in a laboratory setting and daily living…Automated differential diagnosis of Parkinson’s disease and Parkinson-like disorders via motion capture analysis
Objective: The objective of this study is to establish a foundation for an automated differential diagnostic system for Parkinson’s disease (PD) and Parkinson-like disorders (PL)…Detecting Parkinson’s Disease with Postural Sway via Single IMU and Machine Learning
Objective: To determine whether simple standing balance tasks, assessed using a single wearable inertial measurement unit (IMU), can effectively differentiate individuals with Parkinson’s disease (PD)…
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