Explainable deep learning based detection of Parkinson’s changes in MRI brain scans
Objective: A pilot study using an AI-based framework to classify routine brain scans as Parkinson’s disease (PD) or control. Background: Prospective neuroprotective treatments for PD…Sympathetic tone abnormalities in subjects at risk for Parkinson’s Disease without evidence of nigrostriatal neurodegeneration: a multimodal biomarker study
Objective: To study autonomic dysfunction in subjects with idiopathic REM sleep behavior disorder (iRBD) and at least one pre-motor symptom of Parkinson's disease (PD). Background:…Correlation between fatigue, sleep dysfunction and health-related quality of life in Parkinson’s disease patients
Objective: To determine the correlation between fatigue, sleep dysfunction and health-related quality of life in Parkinson’s disease (PD) patients. Background: Fatigue and sleep dysfunction are…Effects of Unilateral and Bilateral DBS of STN, GPi on Voice in PD Patients
Objective: To study the effects of Deep Brain Stimulation (DBS) of subthalamic nucleus (STN) and globus pallidus interna (GPi) on voice in patients with Parkinson’s…Investigating Digital Biomarkers in Parkinson’s Disease
Objective: Our objective is to investigate potential digital biomarkers of Parkinson’s Disease (PD) for early diagnosis and treatment. Background: Parkinson’s disease presents difficulty with early…Sleep hygiene practice in patients with Parkinson’s disease
Objective: We examined the prevalence of diverse sleep hygiene behavior and their associations with insomnia severity in PD patients.We examined the prevalence of diverse sleep…Differences in gray matter atrophy and functional connectivity between motor subtypes of Parkinson’s disease
Objective: This study compared gray matter volume (GMV) and functional connectivity among patients with Parkinson’s disease involving postural instability/gait difficulty (PD-PIGD), patients with tremor-dominant Parkinson’s disease (PD-TD) and healthy…Plasma biomarkers in iRBD patients serve as potential markers of early PD and motor severity
Objective: We aimed to investigate biomarkers of inflammation and neuroaxonal damage in people with isolated REM sleep behaviour disorder (iRBD) compared to controls, and understand…Comparison of biospecimens for α-synuclein seed amplification assays in Parkinson’s disease: A Systematic Review and Network Meta-Analysis
Objective: We performed meta-analysis to determine the diagnostic and differential diagnostic value of α-syn SAAs for PD, and to investigate the optimal specimens. Background: Alpha-synuclein…Non-tremor motor dysfunction in Parkinson’s disease is associated with decreased [18F]FMPEP-d2 binding
Objective: To explore the relationship between cannabinoid receptor type 1 (CB1) availability and motor symptoms in Parkinson’s disease (PD) with [18F]FMPEP-d2 positron emission tomography (PET).…
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