Identification of Allosteric GCase Correctors Using Revenir™ for the Treatment of GBA1-Parkinson’s Disease
Objective: To identify novel non-inhibitory allosteric correctors of GCase using Congruence Therapeutic’s in silico proprietary drug discovery engine, Revenir™ Background: GBA1 encoding for glucocerebrosidase (GCase)…Comparing Pramipexole and Ropinirole in the management of the tremor in Parkinson’s disease in the low-income country and environment of restricted medications.
Objective: To inform the world community about the state situation on Parkinson’s disease in Uzbekistan. Objective: To Co inform the world community about the state…Comparing the Selected Device-Aided Therapy of Movement Disorder Specialist Team with Patient Selections
Objective: This study aims to compare the decision made by patients and physicians in selecting device-aided therapy (DAT) for advanced Parkinson’s disease (aPD) and to…Combining Carbidopa/levodopa Extended-release Capsules and Immediate-release Tablets – Crucial Factors of This Economical Prescription
Objective: We introduced a new way of prescribing carbidopa/levodopa extended-release (ER) capsule – combining use of immediate-release (IR) tablets. This retrospective clinical study was designed…Effectiveness of Subthalamic nucleus (STN) Deep Brain Stimulation Surgery (DBS) in patients with Parkinson’s Disease: A Patient and Caregiver reported outcome
Objective: We aim to assess the subjective impression on effectiveness and safety of Subthalamic nucleus Deep Brain Stimulation Surgery (STN-DBS) in patients with Parkinson’s Disease…The Protective Role of Lysosomal Damage Response in Preventing α-Synuclein Propagation
Objective: The aim of this study was to investigate the mechanism by which the lysosomal damage response (LDR) defends against the escape of α-synuclein (αSyn)…Measures of Mitochondrial Function in Serum across the Parkinson’s Disease Spectrum
Objective: To resolve the inconsistencies in the magnitude and type of mitochondrial dysfunction within peripheral blood mononuclear cells (PBMCs) from people with Parkinson’s disease (PD),…Association of Retinol Binding Protein (RBP) and the Risk of Parkinson’s disease (PD): A Narrative Literature Review
Objective: This review aimed to investigate the association between RBP levels and the risk of Parkinson’s disease Background: RBP facilitates retinol transport from the liver…Association of Striatal Dopaminergic Depletion, Cerebral Perfusion, and Cognitive Outcome in Brain-first and Body-first Parkinson’s Disease
Objective: This study investigated whether brain-first and body-first Parkinson’s disease (PD) showed different pattern of subregional striatal dopamine loss and cerebral perfusion using dual-phase 18F-FP-CIT…Neural Correlates of Dual Task Touchscreen Performance in Parkinson’s Disease
Objective: To compare task-related brain activity during a touchscreen task in Parkinson’s disease (PD) patients and healthy controls (HC) in single (ST) and dual task…
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