Determining and Leveraging Local Ancestry to Assess Individual-Level Risk: from the Global Parkinson’s Genetics Program
Objective: We develop a scalable pipeline leveraging existing tools to determine local ancestry for all individuals in the Global Parkinson’s Genetics Program (GP2), aiming to…Understanding diffusion in extracellular space in synucleinopathy
Objective: To understand the extracellular space (ECS) diffusion in synucleinopathy. Background: The pathogenic mechanisms underlying synucleinopathies involve the spread and propagation of α-synuclein aggregates throughout…Levels of change in interleukin-6 levels according to clinical stages of Parkinson’s disease in patients with and without Covid-19
Objective: Comparison of serum IL-6 levels in clinical stages Parkinson's disease patients with and without Сovid-19. Background: Elevated levels of the cytokine IL-6 may indicate…Age-associated Changes in Microglial Morphology and its Role in Deciphering Susceptibility to Parkinson’s Disease
Objective: To delineate the age-associated changes in microglial morphotypes in the substantia nigra pars compacta (SNpc) of C57BL/6J and CD-1 mice and alterations in response…Neuropeptide Alterations in Parkinson’s Disease: A Meta-Analysis
Objective: To analyze the levels of different neuropeptides in patients with Parkinson’s disease (PD) compared to healthy individuals. Background: Neuropeptides are bioactive molecules that play…Can Square Wave Jerks Differentiate Progressive Supranuclear Palsy from Parkinson’s Disease? A Scoping Review
Objective: To review the available literature regarding the presence and properties of square wave jerks (SWJs) in Progressive Supranuclear Palsy (PSP) and Parkinson’s Disease (PD).…Benefits of Parkinson’s Team Training Are Maintained Long-Term
Objective: To determine if the improvements in confidence to provide and coordinate patient care and understanding of individual and other team member roles among interprofessional…Patient-reported changes from normal in individuals with prodromal and early-motor Parkinson’s disease: a scoping review
Objective: To synthesize published literature about patient-reported symptoms (PRS) or changes from normal in prodromal and early motor stages of Parkinson’s disease (PD) and develop…Study of the functional role of circulating extracellular vesicles as mediators of inflammation in cellular models of Parkinson`s disease
Objective: To study mechanisms of cellular inflammation and neurodegeneration of EVs derived from patients with PD at different disease stages in cell-based disease models. Background:…CSF Neurogranin Levels Are Decreased in Parkinson Disease
Objective: To investigate CSF neurogranin differences in participants with Parkinson disease (PD) and controls and to examine its association with motor and cognitive symptoms. Background:…
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