Developing infrastructure for a multi-arm multi-stage trial in Parkinson’s
Objective: To scope and develop infrastructure for the first multi-arm multi-stage (MAMS) platform trial for Parkinson’s disease, the Edmond J Safra ACT-PD initiative (EJS ACT-PD).…The key is “any movement”: results from a Cochrane systematic review and network meta-analysis on physical interventions for Parkinson´s disease
Objective: To compare the efficacy and safety of physical interventions for people with Parkinson's disease (PD). Background: Physical interventions are effective in managing PD, but…Parkinson disease with LRRK2 mutation associated with upper motor neuron dysfunction
Objective: We report a patient with genetic Parkinson disease associated with upper motor neuron dysfunction. Background: Leucine-rich repeat kinase 2 (LRRK2) mutations have been extensively…Correlation between clinical scales and gait in Parkinson’s disease
Objective: The objective of this study is to verify the correlations between cognitive and motor clinical scales and gait in individuals with PD and whether…The changes in activities of daily livings after deep brain stimulation in Parkinson’s disease
Objective: We aimed to clarify long-term changes in activities of daily living in patients with Parkinson's disease (PD) who underwent deep brain stimulation (DBS). Background:…Personalized Medicine: Assessing the Needs of People with Young-Onset Parkinson’s Disease
Objective: To identify the unmet needs of people with young-onset Parkinson’s disease (YOPD) with the goal of defining future research priorities. Background: YOPD is defined…Socio-Clinical Factors Associated with Parkinson’s Disease Related Specific Self-Management Behaviors: The Role of Non-Motor Symptoms
Objective: To test associations between socio-clinical factors, self-management and patient activation among patients with Parkinson’s disease (PD), and to develop a predictive model for engagement…Impaired behavioral proactive inhibitory control and flexibility in a mouse model of early Parkinson’s disease
Objective: The aim of our study is to address the impact of a moderate nigrostriatal DA lesion induced by 6-hydroxydopamine (6-OHDA) injection into the dorsomedial…Apomorphine Hydrochloride Injection Treatment Initiations in the Presence and Absence of an Antiemetic in People with Parkinson Disease
Objective: To provide real-world experience regarding apomorphine treatment initiations with or without concomitant antiemetic prophylaxis. Background: Apomorphine hydrochloride (apo) injection, administered subcutaneously, is an “on-demand’…The phenomenon of unexpectedly high functional mobility in people with typical Parkinson’s disease. A cross-sectional data analysis.
Objective: To describe the frequency of people with typical Parkinson’s disease (PD) with unexpectedly high functional mobility (a high functional mobility despite the presence of…
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