The Roche ‘End-to-End Matrix’ for Patient-Centric Drug Discovery and Development – Focus on Parkinson’s disease
Objective: To develop an ‘End-to-End Matrix’ for Patient-Centric Drug Discovery and Development to increase the probability of success of clinical trials in Parkinson’s disease. Background:…Cortical gamma oscillations in Parkinson’s disease: ipsi- and contralateral deep brain stimulation-induced entrainment
Objective: To characterize deep brain stimulation (DBS) parameters for bilateral induction of cortical finely tuned gamma (FTG) via unilateral stimulation. Background: FTG oscillations are reported…Cholinergic subtyping in Parkinson disease: differential 2-year interval changes
Objective: To investigate 2-yr interval change in cholinergic transporters in biology-based cholinergic subgroups using serial VAChT [18F]FEOBV brain PET in Parkinson’s disease (PD). Background: Current…Investigation of superficial brain stimulation (SBS) in Parkinsonian rats as a non-invasive alternative treatment for patients with movement disorders
Objective: To investigate repetitive transcranial magnetic stimulation (rTMS) in parkinsonian rats as a non-invasive, malleable superficial brain stimulation (SBS) alternative to DBS. Background: DBS is…Pain and sleep in Parkinson’s disease
Objective: Pain and sleep disturbances are among the most frequently encountered non-motor symptoms in Parkinson’s disease (PD). Background: The aim of this study was to…Gluten-free diet in Parkinson’s disease patients – feasibility, safety and preliminary results
Objective: The primary objective of this project is to evaluate the effect of long administered gluten-free diet (GFD) on motor symptoms of Parkinson's disease (PD).…How helpful is the Swallow tail sign in Parkinson’s disease?
Objective: To report a patient diagnosed with idiopathic Parkinson’s disease (PD) with an intact Swallow tail sign (STS) shown in his MR susceptibility-weighted imaging (SWI)…Differences in patients with Impulse Control Disorder based on antiparkinsonian drug treatment in a Mexican Institute.
Objective: To describe the differences in multiple factors based on Parkinson's treatment in patients with impulse control disorder Background: In intermediate-advanced phases of PE, psychiatric…Machine Learning Prediction of Motor Score Reduction following DBS Surgery in PD
Objective: This study investigates several machine learning methods for predicting motor score reduction following DBS surgery in patients with PD using multi-modal feature selection. Background:…Characteristics of cases in which stimulation was programmed for multiple targets in deep brain stimulation therapy for Parkinson’s disease.
Objective: To clarify the the clinical background of Parkinson's disease patients with DBS who received multiple stimulus targets. Background: Deep brain stimulation (DBS) is an…
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