Genetic contribution to domain specific cognitive decline
Objective: To assess differences in cognitive domains between patients with Parkinson’s disease with the LRRK2 and GBA risk mutations Background: Most patients with PD show…Biochemical markers of glucocerebrosidase (GCase) deficiency in primary macrophages derived from GBA1 mutation carriers with and without Parkinson’s disease
Objective: The aim of the present study was to assess biochemical markers in primary macrophages that could distinguish patient with Parkinson’s disease linked to mutations…Binaural acoustic stimulation reduces tremor severity in patients suffering from Parkinson’s disease
Objective: To assess the effects of BBS on motor symptoms in PD. Background: Acoustic stimulation (AS) can improve motor symptoms in Parkinson’s disease (PD) and…Validation of the PD Home Diary for Assessment of Motor Fluctuations in Advanced Parkinson’s Disease
Objective: To determine the validity of the Parkinson’s disease (PD) home diary for quantification of motor states in patients with advanced PD and motor fluctuations.…A randomized clinical trial (RCT) to evaluate the effects of safinamide on apathetic non-demented Parkinson’s disease patients
Objective: To evaluate the safety and effects of add-on safinamide on apathy in patients with Parkinson’s disease (PD). Background: Apathy is highly prevalent and disabling…Network Fingerprint of Stimulation-Induced Speech Impairment in Parkinson’s Disease
Objective: To explore structural network correlates of stimulation-induced dysarthria (SID) in patients with Parkinson’s Disease (PD) chronically treated with deep brain stimulation (DBS) of the…Remote keyboard tapping: potential signatures of early motor dysfunction in isolated REM sleep behaviour disorder
Objective: To compare keyboard tapping performance in people with iRBD with controls. Background: The Distal Finger Tapping (DFT)1 test and BRadykineisa Akinesia Incoordination test (BRAIN)2…Cholinergic Innervation and Cognitive Functioning in De Novo Parkinson’s Patients with GBA Variations
Objective: To explore the regional cholinergic innervation and clinical characteristics of de novo Parkinson’s disease (PD) patients carrying GBA variants. Background: The most common genetic…Asymmetry of Motor and Non-motor Signs in Parkinson’s Disease: An Exploratory Clinical Case-control Study
Objective: To identify, quantify and correlate asymmetry between motor and non-motor signs in early Parkinson’s disease (PD). Background: Asymmetry of motor signs in PD reflects…Resistance training in patients with Parkinson’s disease: a systematic review and meta-analysis
Objective: To analyze the effects of resistance training (RT) on motor- and non-motor outcomes in patients with Parkinson's disease (PD) compared to passive and physically…
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