LIPAD (LRRK2/Luebeck) International Parkinson’s Disease Study: Protocol and feasibility study
Objective: To systematically assess clinical signs and symptoms including non-motor features, comorbidities, medication and environmental factors in 1,000 participants internationally: 300 with LRRK2 (Leucine-rich repeat…Next-generation sequencing of plasma-associated extracellular vesicle miRNAs as potential biomarkers for Parkinson’s disease and its prodromal stage
Objective: This study aimed to identify subsets of plasma EV-associated miRNAs with diagnostic potential for PD and iRBD, the prodromal stage of PD. Background: Parkinson’s…Cortical microstructural alterations are more sensitive than morphology changes to cortical degeneration in Parkinson’s disease with mild cognitive impairment
Objective: To compare the sensitivity of detection cortical degenerative changes in patients with Parkinson’s disease (PD) and mild cognitive impairment (MCI) between the diffusion magnetic…EVOLUTION OF PARKINSON’S DISEASE IN PATIENTS WITH ESSENTIAL TREMOR: CLINICAL AND NEUROIMAGING ASPECTS
Objective: Analyze the result of the SPECT-TRODAT image exam in patients with ET and to evaluate the predictive value of a possible evolution to the…Sexual divergencies in monoaminergic projections in Parkinson’s disease: a 123I-FP-CIT SPECT study
Objective: To investigate sex differences in nigrostriatal and extrastriatal 123I-FP-CIT SPECT monoaminergic projections in healthy subjects and Parkinson’s disease (PD) Background: preclinical and clinical studies suggest…Dysfunctional resting connectivity in early stage of Parkinson’s disease is indistinguishable from connectivity in REM sleep behaviour disorder
Objective: To investigate the differences in functional connectivity among healthy subjects (HC), patients with REM sleep behaviour disorder (RBD) and levodopa-naïve patients in early stage…Normal-sized Perivascular Space in Basal Ganglia Related to Motor Phenotypes in Parkinson Freezers
Objective: With 7T MRI, we aimed to study the relationship between the initial motor phenotype of Parkinson’s disease (PD) and normal-sized PVSs (nPVSs) burden in…Longitudinal changes of gait parameters in early Parkinson’s disease
Objective: To analyse changes in quantitative gait parameters in patients with very early, unilateral, PD over 12 months follow-up. Background: Parkinson’s disease (PD) is frequently characterized by progressive gait…Relationship between low back pain-related disability and motor performance in people with Parkinson disease
Objective: To determine the relationship between low back pain (LBP)-related disability and physical performance in people with Parkinson disease (PD). Background: Low back pain is…Hyperhidrosis in Parkinson’s disease: a 3-year prospective cohort study
Objective: We conducted a 3-year prospective longitudinal study to investigate the development, evolution, correlates, and predictors of hyperhidrosis in patients with early-stage Parkinson's disease (PD).…
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